Ganglioside alterations in guinea pig brains at end stages of experimental Creutzfeldt-Jakob disease

Robert K. Yu, Elias E. Manuelidis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Gangliosides were isolated from guinea pig brains at the end stages of experimental Creutzfeldt-Jakob disease. Quantitative analyses revealed marked decreases of ganglioside levels in pathologically devastated tissues such as cerebral cortex (-21%), basal ganglia and thalamus (-18%), and brain stem (-23%). The cerebellum revealed only minor pathological abnormalities and its ganglioside level remained unchanged. Thin-layer chromatography of the Creutzfeldt-Jakob brain gangliosides showed aberrant ganglioside patterns in all regions studied, including the cerebellum. With some exceptions, a trend in ganglioside pattern changes was detected which consisted of proliferation of GM3, GD3, GD2 and loss of GM1, GD1a, GD1b and GT1b** ** The ganglioside nomenclature system of Svennerholm (1963) is used. The structures of some of the gangliosides have been compiled recently (Ledeen and Yu 1976)..

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalJournal of the Neurological Sciences
Volume35
Issue number1
DOIs
StatePublished - Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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