TY - JOUR
T1 - Ganglioside alterations in guinea pig brains at end stages of experimental Creutzfeldt-Jakob disease
AU - Yu, Robert K.
AU - Manuelidis, Elias E.
N1 - Funding Information:
This work was supported by USPHS Grants NS-11853 and NS-12674, and in part by grants from The Kroc Foundation and The Klingenstein Fund.
PY - 1978/1
Y1 - 1978/1
N2 - Gangliosides were isolated from guinea pig brains at the end stages of experimental Creutzfeldt-Jakob disease. Quantitative analyses revealed marked decreases of ganglioside levels in pathologically devastated tissues such as cerebral cortex (-21%), basal ganglia and thalamus (-18%), and brain stem (-23%). The cerebellum revealed only minor pathological abnormalities and its ganglioside level remained unchanged. Thin-layer chromatography of the Creutzfeldt-Jakob brain gangliosides showed aberrant ganglioside patterns in all regions studied, including the cerebellum. With some exceptions, a trend in ganglioside pattern changes was detected which consisted of proliferation of GM3, GD3, GD2 and loss of GM1, GD1a, GD1b and GT1b** ** The ganglioside nomenclature system of Svennerholm (1963) is used. The structures of some of the gangliosides have been compiled recently (Ledeen and Yu 1976)..
AB - Gangliosides were isolated from guinea pig brains at the end stages of experimental Creutzfeldt-Jakob disease. Quantitative analyses revealed marked decreases of ganglioside levels in pathologically devastated tissues such as cerebral cortex (-21%), basal ganglia and thalamus (-18%), and brain stem (-23%). The cerebellum revealed only minor pathological abnormalities and its ganglioside level remained unchanged. Thin-layer chromatography of the Creutzfeldt-Jakob brain gangliosides showed aberrant ganglioside patterns in all regions studied, including the cerebellum. With some exceptions, a trend in ganglioside pattern changes was detected which consisted of proliferation of GM3, GD3, GD2 and loss of GM1, GD1a, GD1b and GT1b** ** The ganglioside nomenclature system of Svennerholm (1963) is used. The structures of some of the gangliosides have been compiled recently (Ledeen and Yu 1976)..
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U2 - 10.1016/0022-510X(78)90098-9
DO - 10.1016/0022-510X(78)90098-9
M3 - Article
C2 - 342675
AN - SCOPUS:0017927888
SN - 0022-510X
VL - 35
SP - 15
EP - 23
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -