Ganglioside metabolism in a transgenic mouse model of alzheimer's disease: Expression of chol-1α antigens in the brain

Toshio Ariga, Makoto Yanagisawa, Chandramohan Wakade, Susumu Ando, Jerry J. Buccafusco, Michael P. McDonald, Robert K. Yu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The accumulation of Aβ (amyloid β-protein) is one of the major pathological hallmarks in AD (Alzheimer's disease). Gangliosides, sialic acid-containing glycosphingolipids enriched in the nervous system and frequently used as biomarkers associated with the biochemical pathology of neurological disorders, have been suggested to be involved in the initial aggregation of Aβ. In the present study, we have examined ganglioside metabolism in the brain of a double-Tg (transgenic) mouse model of AD that co-expresses mouse/human chimaeric APP (amyloid precursor protein) with the Swedish mutation and human presenilin-1 with a deletion of exon 9. Although accumulation of Aβ was confirmed in the double-Tg mouse brains and sera, no statistically significant change was detected in the concentration and composition of major ganglio-N-tetraosyl-series gangliosides in the double-Tg brain. Most interestingly, Chol-1α antigens (cholinergic neuron-specific gangliosides), such as GT1aα and GQ1bα, which are minor species in the brain, were found to be increased in the double-Tg mouse brain. We interpret that the occurrence of these gangliosides may represent evidence for generation of cholinergic neurons in the AD brain, as a result of compensatory neurogenesis activated by the presence of Aβ.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalASN Neuro
Volume2
Issue number4
DOIs
StatePublished - Oct 29 2010

Keywords

  • Alzheimer's disease
  • Amyloid β-peptide
  • Antigen
  • Chol-1α
  • Cholinergic neuron
  • Ganglioside
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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