Gastrulation Defective protease interacts with anionic components of the drosophila ovary extracellular matrix

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Abstract

The Drosophila proteases Gastrulation Defective and Snake function in embryonic polarity establishment and bind heparin, a surrogate for anionic species present in the extracellular matrix. Here we demonstrate binding of GD, but not Snake, to anionic species that appear to be tightly associated with a highly purified eggshell matrix.

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalProtein and Peptide Letters
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Drosophila
  • Embryonic polarity
  • Gastrulation Defective
  • Pipe
  • Serine protease cascade
  • Snake

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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