Geant4 estimation model of high Z atom concentration for tumor vessel ablation

Ke Huang, Anil Pradhan, Sultana Nahar, Maximiliano Montenegro, Kaiguo Yan, Yan Yu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In our novel technique of tumor vessels treatment, High Z (HZ) contrast atoms are injected into the blood vessel and the tumor region is irradiated with "narrowband" fluorescence photon (FP) beam tuned to the "resonance energies". Theoretically, this technique guarantees a dose 102 - 103 higher than that achieved in conventional radiation therapy (RT). Meanwhile, this high dose is confined to a region of tens of micrometers. This will minimize the side effects caused by the high dose to the surrounding tissues. The FPs are generated by electrons impinging onto target made of the same material as the HZ contrast. In order to support the experiment, an estimation model has been developed based on Geant4 Monte Carlo (MC) simulation. This model takes into account physical and biological factors, which can be determined separately. In this work, the derivation of the model was described in detail, and four HZ atoms, gadolinium (Gd), platinum (Pt), gold (Au) and uranium (U) were evaluated using the model. The scaling law for the capability to yield FPs from IEs had been deduced for these HZ atoms. The results also showed that the minimum molar concentration required for apoptosis of tumor endothelial cells (ECs) for Gd, Pt, Au and U in normal experimental condition were 220.44 nmol/ml, 55.57 nmol/ml, 49.78 nmol/ml and 9.05 nmol/ml, respectively.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages3060-3063
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Dec 1 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Gadolinium
Ablation
Platinum
Tumors
Vascular Tissue Neoplasms
Atoms
Uranium
Biological Factors
Photons
Gold
Neoplasms
Radiotherapy
Endothelial Cells
Fluorescence
Electrons
Apoptosis
Scaling laws
Endothelial cells
Blood vessels
Cell death

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Huang, K., Pradhan, A., Nahar, S., Montenegro, M., Yan, K., & Yu, Y. (2009). Geant4 estimation model of high Z atom concentration for tumor vessel ablation. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009 (pp. 3060-3063). [5334003] IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334003

Geant4 estimation model of high Z atom concentration for tumor vessel ablation. / Huang, Ke; Pradhan, Anil; Nahar, Sultana; Montenegro, Maximiliano; Yan, Kaiguo; Yu, Yan.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 3060-3063 5334003.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Huang, K, Pradhan, A, Nahar, S, Montenegro, M, Yan, K & Yu, Y 2009, Geant4 estimation model of high Z atom concentration for tumor vessel ablation. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009., 5334003, IEEE Computer Society, pp. 3060-3063, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334003
Huang K, Pradhan A, Nahar S, Montenegro M, Yan K, Yu Y. Geant4 estimation model of high Z atom concentration for tumor vessel ablation. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 3060-3063. 5334003 https://doi.org/10.1109/IEMBS.2009.5334003
Huang, Ke ; Pradhan, Anil ; Nahar, Sultana ; Montenegro, Maximiliano ; Yan, Kaiguo ; Yu, Yan. / Geant4 estimation model of high Z atom concentration for tumor vessel ablation. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 3060-3063
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