Abstract
Background: The Hsp90 chaperoning machine is an exciting therapeutic target for cancer treatment. Results: We report that the natural product gedunin inactivates the Hsp90 co-chaperone p23 in vitro and in vivo. The lethal effect of gedunin-p23 complex on cancer cells is amplified by caspase-7-mediated cleavage of the co-chaperone, leading to apoptotic cell death. Conclusions: Gelduin binds directly to p23 leading to inactivation of the Hsp90 machine and selective destabilization of steroid receptors. Significance: Gedunin is a promising compound to develop anti-cancer therapeutics.
Original language | English (US) |
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Pages (from-to) | 7313-7325 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 10 |
DOIs | |
State | Published - Mar 8 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology