Gender and age differences in growth factor concentrations from platelet-rich plasma in adults

Richard Evanson, M. Kelly Guyton, Avid L. Oliver, Justin M. Hire, Richard L. Topolski, Steven D. Zumbrun, James C. McPherson, John A. Bojescul

Research output: Contribution to journalArticle

Abstract

The use of platelet-rich plasma (PRP) to facilitate healing of orthopedic-related injuries has gained popularity; however, the clinical benefits are not consistent. Differences may result from variations in growth factor (GF) levels in normal populations. The purpose of this study was to determine if GF levels present in activated PRP preparations differed by gender and age (<25 versus >25 years) in a healthy population (N = 102). All GFs analyzed (epidermal growth factor [EGF], hepatocyte growth factor [HGF], insulin growth factor-1 [1GF-1], platelet-derived growth factor-AB [PDGF-AB], platelet-derived growth factor-BB [PDGF-BB], transforming growth factor beta-l ITGFβ-11, and vascular endothelial growth factor) had higher levels for females and for those <25 years old. Of the GFs tested, four of seven were significantly higher (p < 0.05) for females (EGF, HGF, 1GF-1, PDGF-BB), the most significant being IGF-I (female, 85.0; male, 69.3 ng/mL; p < 0.01). Five of seven GFs achieved significance (p < 0.05) for people <25 years old (EGF, IGF-1, PDGP-AB, PDGF-BB, and TGFβ-1), with IGF and PDGF-AB achieving p < 0.001 (<25 years, 85.1; >25 years, 56.8, and <25 years, 7.66; >25 years, 5.77 ng/mL, respectively). Finally, for both genders, most of the GFs were positively correlated with all GFs. This study demonstrated that both age and gender account for variations in specific GFs present in PRP, and this may partially explain some of the inconsistent results of PRP clinical trials.

Original languageEnglish (US)
Pages (from-to)799-805
Number of pages7
JournalMilitary Medicine
Volume179
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

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Platelet-Rich Plasma
Intercellular Signaling Peptides and Proteins
Hepatocyte Growth Factor
Epidermal Growth Factor
Transforming Growth Factor beta
Vascular Endothelial Growth Factor A
Population
Orthopedics
Clinical Trials
Insulin
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health

Cite this

Evanson, R., Kelly Guyton, M., Oliver, A. L., Hire, J. M., Topolski, R. L., Zumbrun, S. D., ... Bojescul, J. A. (2014). Gender and age differences in growth factor concentrations from platelet-rich plasma in adults. Military Medicine, 179(7), 799-805. https://doi.org/10.7205/M11.MED-D-13-00336

Gender and age differences in growth factor concentrations from platelet-rich plasma in adults. / Evanson, Richard; Kelly Guyton, M.; Oliver, Avid L.; Hire, Justin M.; Topolski, Richard L.; Zumbrun, Steven D.; McPherson, James C.; Bojescul, John A.

In: Military Medicine, Vol. 179, No. 7, 2014, p. 799-805.

Research output: Contribution to journalArticle

Evanson, R, Kelly Guyton, M, Oliver, AL, Hire, JM, Topolski, RL, Zumbrun, SD, McPherson, JC & Bojescul, JA 2014, 'Gender and age differences in growth factor concentrations from platelet-rich plasma in adults', Military Medicine, vol. 179, no. 7, pp. 799-805. https://doi.org/10.7205/M11.MED-D-13-00336
Evanson, Richard ; Kelly Guyton, M. ; Oliver, Avid L. ; Hire, Justin M. ; Topolski, Richard L. ; Zumbrun, Steven D. ; McPherson, James C. ; Bojescul, John A. / Gender and age differences in growth factor concentrations from platelet-rich plasma in adults. In: Military Medicine. 2014 ; Vol. 179, No. 7. pp. 799-805.
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