Gender differences and comorbidities in U.S. Adults with bipolar disorder

Rikinkumar S. Patel, Sanya Virani, Hina Saeed, Sai Nimmagadda, Jupi Talukdar, Nagy Adel Youssef

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Past studies have evaluated the association of various comorbidities with bipolar disorder. This study analyzes differences in the prevalence and association of medical and psychiatric comorbidities in bipolar patients by gender. Methods: A retrospective analysis was conducted using the Nationwide Inpatient Sample (2010–2014). Using International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes, we narrowed the study population to comprise those with a primary diagnosis of bipolar disorder and then obtained information about comorbidities. The differences in comorbidities by gender were quantified using chi-square tests and the logistic regression model (odds ratio (OR)). Results: Hypertension (20.5%), asthma (12.5%) and hypothyroidism (8.1%) were the top medical comorbidities found in bipolar patients. Migraine and hypothyroidism were seen three times higher in females (OR = 3.074 and OR = 3.001; respectively). Females with bipolar disorder had higher odds of comorbid inflammatory disorders like asthma (OR = 1.755), Crohn’s disease (OR = 1.197) and multiple sclerosis (OR = 2.440) compared to males. Females had a two-fold higher likelihood of comorbid post-traumatic stress disorder (PTSD) (OR = 2.253) followed by personality disorders (OR = 1.692) and anxiety disorders (OR = 1.663) compared to males. Conclusion: Women with bipolar disorder have a much higher medical comorbidity burden than men and may highly benefit from an integrated team of physicians to manage their condition and improve their health-related quality of life.

Original languageEnglish (US)
Article number168
JournalBrain Sciences
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2018

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Bipolar Disorder
Comorbidity
Odds Ratio
Hypothyroidism
Asthma
Logistic Models
Personality Disorders
International Classification of Diseases
Chi-Square Distribution
Post-Traumatic Stress Disorders
Anxiety Disorders
Migraine Disorders
Crohn Disease
Multiple Sclerosis
Psychiatry
Inpatients
Quality of Life
Hypertension
Physicians
Population

Keywords

  • Bipolar disorder
  • Comorbidities
  • Gender differences
  • Inpatient psychiatry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gender differences and comorbidities in U.S. Adults with bipolar disorder. / Patel, Rikinkumar S.; Virani, Sanya; Saeed, Hina; Nimmagadda, Sai; Talukdar, Jupi; Youssef, Nagy Adel.

In: Brain Sciences, Vol. 8, No. 9, 168, 01.09.2018.

Research output: Contribution to journalArticle

Patel, Rikinkumar S. ; Virani, Sanya ; Saeed, Hina ; Nimmagadda, Sai ; Talukdar, Jupi ; Youssef, Nagy Adel. / Gender differences and comorbidities in U.S. Adults with bipolar disorder. In: Brain Sciences. 2018 ; Vol. 8, No. 9.
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