Gender differences in host defense mechanisms

Joseph Gerard Cannon, Barbara A. St. Pierre

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Extensive studies in both humans and animals have shown that females express enhanced levels of immunoreactivity compared to males. Whereas this provides females with increased resistance to many types of infection, it also makes them more susceptible to autoimmune diseases. This review will focus on gender-related differences in non-specific host defense mechanisms with a particular emphasis on monocyte/macrophage function and a primary product of monocytes: interleukin-1 (IL-1). Immunomodulatory cytokines such as IL-1 are influenced by gender-sensitive hormones, and reciprocally, these cytokines influence gender-specific hormones and tissues. Patients with chronic fatigue syndrome (CFS) are predominantly women, therefore it may be useful to look toward gender-specific differences in immune function to find a key for this poorly understood syndrome.

Original languageEnglish (US)
Pages (from-to)99-113
Number of pages15
JournalJournal of Psychiatric Research
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1997

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Interleukin-1
Monocytes
Hormones
Cytokines
Chronic Fatigue Syndrome
Autoimmune Diseases
Macrophages
Infection

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Gender differences in host defense mechanisms. / Cannon, Joseph Gerard; St. Pierre, Barbara A.

In: Journal of Psychiatric Research, Vol. 31, No. 1, 01.01.1997, p. 99-113.

Research output: Contribution to journalArticle

Cannon, Joseph Gerard ; St. Pierre, Barbara A. / Gender differences in host defense mechanisms. In: Journal of Psychiatric Research. 1997 ; Vol. 31, No. 1. pp. 99-113.
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