Gender differences in total and allergen-specific immunoglobulin E (IgE) concentrations in a population-based cohort from birth to age four years

Christine Cole Johnson, Edward L. Peterson, Dennis Randall Ownby

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

While serum immunoglobulin E (IgE) concentration has been shown to be related to allergic disease, there have been few studies of the natural history of IgE development in young children. This study compared total and allergen-specific serum IgE concentrations, by gender, from birth through 4 years of age using a population-based cohort of normal children followed from 1987 to 1993. Subjects were enrolled from a geographically defined area through membership in a large health maintenance organization, and they resided in the northern suburbs of Detroit, Michigan. Total IgE concentrations were measured at birth and at 2 and 4 years of age. Specific IgE concentrations to selected common inhalant allergens (dust mite (Dematophagoides farinae), cat, ragweed (Ambrosia artemisiifolia), and timothy grass (Pheleum pratense)) were measured at 2 and 4 years of age. Total IgE increased with age from birth to 4 years for boys and girls, and was higher in boys at 2 and 4 years of age. Girls demonstrated significant increases in IgE to mite and cat and decreases in IgE to ragweed and timothy from 2 to 4 years of age, whereas there was little change for boys except an increase in IgE to ragweed. Differences in tgE development between young boys and girls may partially account for the higher prevalence of asthma in boys than in girls.

Original languageEnglish (US)
Pages (from-to)1145-1152
Number of pages8
JournalAmerican Journal of Epidemiology
Volume147
Issue number12
DOIs
StatePublished - Jun 15 1998
Externally publishedYes

Fingerprint

Allergens
Immunoglobulin E
Parturition
Ambrosia
Population
Mites
Cats
Phleum
Health Maintenance Organizations
Natural History
Dust
Serum
Asthma

Keywords

  • Gender
  • IgE
  • Pediatrics

ASJC Scopus subject areas

  • Epidemiology

Cite this

Gender differences in total and allergen-specific immunoglobulin E (IgE) concentrations in a population-based cohort from birth to age four years. / Johnson, Christine Cole; Peterson, Edward L.; Ownby, Dennis Randall.

In: American Journal of Epidemiology, Vol. 147, No. 12, 15.06.1998, p. 1145-1152.

Research output: Contribution to journalArticle

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