Gender influences endothelial-dependent arterial dilatation via arterial size in youth

Kakota Gaston Kapuku, Frank A. Treiber, Bryan Hartley, David A. Ludwig

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Reduced endothelial-dependent arterial dilatation (EDAD) has been suggested as an early marker of arteriosclerosis, since it has been reported to correlate with known cardiovascular disease (CVD) risk factors. It is unclear, however, whether gender plays a mediating or a moderating role in these relationships. The aim of this study was to evaluate the influence of gender on EDAD in youth at risk for CVD. Methods: The sample population of 261 individuals (mean age, 20 yr; SD, 3 yr) consisted of 148 African Americans, 113 European Americans, 133 males, and 128 females, all with a verified family history of CVD (ie, hypertension, myocardial infarction). Anthropometrics, sociometrics, hemodynamics, brachial artery diameter, left ventricular mass, and relative wall thickness were measured and used as independent variables. EDAD (dependent variable) was expressed as percent (%) change of brachial artery diameter to reactive hyperemia induced by pressure cuff occlusion and release. Artery diameters were calculated via an automated border detection system. Results: Percent EDAD change was inversely related to initial diameter of the brachial artery. Mean percent EDAD change was 14.37% for female subjects compared with 10.48% for male subjects. The gender difference was a function of smaller initial artery size in the female subjects. When initial diameter and gender were considered simultaneously within a multivariate model, the gender effect was eliminated. Although a large prediameter effect remained, the relationship between prediameter and EDAD was greater in female than in male subjects (ie, interaction/moderating effect). Conclusion: The data suggest that the smaller the artery is, the more it will dilate. Further EDAD investigations are needed to predict arteriosclerosis, taking into account of the gender difference in vessel size.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume327
Issue number6
DOIs
StatePublished - Jan 1 2004

Fingerprint

Dilatation
Brachial Artery
Cardiovascular Diseases
Arteries
Arteriosclerosis
Hyperemia
African Americans
Hemodynamics
Myocardial Infarction
Hypertension
Pressure
Population

Keywords

  • Endothelial function
  • Gender
  • Youth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gender influences endothelial-dependent arterial dilatation via arterial size in youth. / Kapuku, Kakota Gaston; Treiber, Frank A.; Hartley, Bryan; Ludwig, David A.

In: American Journal of the Medical Sciences, Vol. 327, No. 6, 01.01.2004, p. 305-309.

Research output: Contribution to journalArticle

Kapuku, Kakota Gaston ; Treiber, Frank A. ; Hartley, Bryan ; Ludwig, David A. / Gender influences endothelial-dependent arterial dilatation via arterial size in youth. In: American Journal of the Medical Sciences. 2004 ; Vol. 327, No. 6. pp. 305-309.
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