Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood

Study on toxicogenomics and prevention targeting

Zhaohui Wang, Hongliang Hu, Jie Zheng, Biaoru Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.

Original languageEnglish (US)
Title of host publicationProceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Pages72-77
Number of pages6
DOIs
StatePublished - Dec 27 2011
Externally publishedYes
Event2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 - Taichung, Taiwan, Province of China
Duration: Oct 24 2011Oct 26 2011

Publication series

NameProceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011

Other

Other2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
CountryTaiwan, Province of China
CityTaichung
Period10/24/1110/26/11

Fingerprint

T-cells
Gene expression
Liver
Tumors
Blood
Poisons
Genes
Immunology
Toxicogenetics
Cells
Tissue

Keywords

  • gene expression
  • pathway analysis
  • prevention targeting
  • quiescent CD8+ T cells
  • toxicogenomics

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Wang, Z., Hu, H., Zheng, J., & Li, B. (2011). Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 (pp. 72-77). [6089810] (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011). https://doi.org/10.1109/BIBE.2011.18

Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : Study on toxicogenomics and prevention targeting. / Wang, Zhaohui; Hu, Hongliang; Zheng, Jie; Li, Biaoru.

Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 72-77 6089810 (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, Z, Hu, H, Zheng, J & Li, B 2011, Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. in Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011., 6089810, Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011, pp. 72-77, 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011, Taichung, Taiwan, Province of China, 10/24/11. https://doi.org/10.1109/BIBE.2011.18
Wang Z, Hu H, Zheng J, Li B. Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 72-77. 6089810. (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011). https://doi.org/10.1109/BIBE.2011.18
Wang, Zhaohui ; Hu, Hongliang ; Zheng, Jie ; Li, Biaoru. / Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : Study on toxicogenomics and prevention targeting. Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. pp. 72-77 (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011).
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