TY - GEN
T1 - Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood
T2 - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
AU - Wang, Zhaohui
AU - Hu, Hongliang
AU - Zheng, Jie
AU - Li, Biaoru
PY - 2011
Y1 - 2011
N2 - The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.
AB - The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.
KW - gene expression
KW - pathway analysis
KW - prevention targeting
KW - quiescent CD8+ T cells
KW - toxicogenomics
UR - http://www.scopus.com/inward/record.url?scp=84155191325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84155191325&partnerID=8YFLogxK
U2 - 10.1109/BIBE.2011.18
DO - 10.1109/BIBE.2011.18
M3 - Conference contribution
AN - SCOPUS:84155191325
SN - 9780769543918
T3 - Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
SP - 72
EP - 77
BT - Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Y2 - 24 October 2011 through 26 October 2011
ER -
