Gene expression profiling of Non-small cell lung cancer

Sunil Singhal, Daniel Miller, Suresh Ramalingam, Shi Yong Sun

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Functional genomics has emerged over the past 10 years as a novel technology to study genetic alterations. Gene expression arrays are one genomic technique employed to discover changes in the DNA expression that occur in neoplastic transformation. Microarrays have been applied to investigating lung cancer. Specific applications include discovering novel genetic changes that occur in lung tumors. Microarrays can also be applied to improve diagnosis, staging and discover prognostic markers. The eventual goal of this technology is to discover new markers for therapy and to customize therapy based on an individual tumor genetic composition. In this review, we present the current state of gene expression array technology in its application to lung cancer.

Original languageEnglish (US)
Pages (from-to)313-324
Number of pages12
JournalLung Cancer
Issue number3
StatePublished - Jun 2008
Externally publishedYes


  • Diagnosis
  • Gene expression arrays
  • Gene expression profiling
  • Genomics
  • Lung cancer
  • Management
  • Prognosis
  • Staging
  • Therapy
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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