Gene therapy of benign gynecological diseases

Memy H. Hassan, Essam E. Othman, Daniela Hornung, Ayman Al-Hendy

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes; immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis.

Original languageEnglish (US)
Pages (from-to)822-835
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume61
Issue number10
DOIs
StatePublished - Aug 10 2009

Keywords

  • Adenovirus
  • Endometriosis
  • Gene therapy
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Hassan, M. H., Othman, E. E., Hornung, D., & Al-Hendy, A. (2009). Gene therapy of benign gynecological diseases. Advanced Drug Delivery Reviews, 61(10), 822-835. https://doi.org/10.1016/j.addr.2009.04.023