Gene therapy of benign gynecological diseases

Memy H. Hassan, Essam E. Othman, Daniela Hornung, Ayman Al-Hendy

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes; immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis.

Original languageEnglish (US)
Pages (from-to)822-835
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume61
Issue number10
DOIs
StatePublished - Aug 10 2009

Fingerprint

Genetic Therapy
Genes
Leiomyoma
Endometriosis
Technology Transfer
Tumor Suppressor Genes
Oncogenes
Suicide
Molecular Biology
Mutation
Therapeutics

Keywords

  • Adenovirus
  • Endometriosis
  • Gene therapy
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Hassan, M. H., Othman, E. E., Hornung, D., & Al-Hendy, A. (2009). Gene therapy of benign gynecological diseases. Advanced Drug Delivery Reviews, 61(10), 822-835. https://doi.org/10.1016/j.addr.2009.04.023

Gene therapy of benign gynecological diseases. / Hassan, Memy H.; Othman, Essam E.; Hornung, Daniela; Al-Hendy, Ayman.

In: Advanced Drug Delivery Reviews, Vol. 61, No. 10, 10.08.2009, p. 822-835.

Research output: Contribution to journalReview article

Hassan, MH, Othman, EE, Hornung, D & Al-Hendy, A 2009, 'Gene therapy of benign gynecological diseases', Advanced Drug Delivery Reviews, vol. 61, no. 10, pp. 822-835. https://doi.org/10.1016/j.addr.2009.04.023
Hassan, Memy H. ; Othman, Essam E. ; Hornung, Daniela ; Al-Hendy, Ayman. / Gene therapy of benign gynecological diseases. In: Advanced Drug Delivery Reviews. 2009 ; Vol. 61, No. 10. pp. 822-835.
@article{ceedea4410514cb0993e42278ca4e03c,
title = "Gene therapy of benign gynecological diseases",
abstract = "Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes; immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis.",
keywords = "Adenovirus, Endometriosis, Gene therapy, Uterine leiomyoma",
author = "Hassan, {Memy H.} and Othman, {Essam E.} and Daniela Hornung and Ayman Al-Hendy",
year = "2009",
month = "8",
day = "10",
doi = "10.1016/j.addr.2009.04.023",
language = "English (US)",
volume = "61",
pages = "822--835",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "10",

}

TY - JOUR

T1 - Gene therapy of benign gynecological diseases

AU - Hassan, Memy H.

AU - Othman, Essam E.

AU - Hornung, Daniela

AU - Al-Hendy, Ayman

PY - 2009/8/10

Y1 - 2009/8/10

N2 - Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes; immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis.

AB - Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes; immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis.

KW - Adenovirus

KW - Endometriosis

KW - Gene therapy

KW - Uterine leiomyoma

UR - http://www.scopus.com/inward/record.url?scp=67649224010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649224010&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2009.04.023

DO - 10.1016/j.addr.2009.04.023

M3 - Review article

C2 - 19446586

AN - SCOPUS:67649224010

VL - 61

SP - 822

EP - 835

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 10

ER -