Genetic and environmental determinants of lipid profile in Black and White youth

A study of four candidate genes

Catherine Lucy Davis, Xiaoling Wang, Harold Sneider, Frank A. Treiber

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. Design, Setting, Participants: Healthy adolescents and young adults (N=413, 18.6 ± 2.8 yrs, 44% Black, 53% Male) drawn from a cardiovascular study. Main outcome measures: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARγ Pro12Ala, and TNFα -308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. Results: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/M2, 0.54 at BMI=40, P< .05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFα allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/L, P<.01). No effect of the PPARγ Pro12Ala polymorphism was found; the 12Ala PPARγ allele was rare among Blacks (2%). Conclusions: The ApoB, TNFα, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7%), may contribute to lower TG in Blacks. The -308A TNFα allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)568-577
Number of pages10
JournalEthnicity and Disease
Volume15
Issue number4
StatePublished - Sep 1 2005

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Apolipoproteins B
Alleles
Lipids
LDL Receptors
Peroxisome Proliferator-Activated Receptors
Body Mass Index
Genes
HDL Cholesterol
Gene-Environment Interaction
Cholesterol
Triglycerides
Tumor Necrosis Factor Receptors
Homozygote
hydroquinone
Hypercholesterolemia
Social Class
Young Adult
Atherosclerosis
Healthy Volunteers
Obesity

Keywords

  • Adolescents
  • Body mass index
  • Cardiovascular
  • Cholesterol
  • Continental population groups
  • HDL lipoproteins
  • Polymorphism
  • Risk factors
  • Triglycerides
  • Young adults

ASJC Scopus subject areas

  • Epidemiology

Cite this

Genetic and environmental determinants of lipid profile in Black and White youth : A study of four candidate genes. / Davis, Catherine Lucy; Wang, Xiaoling; Sneider, Harold; Treiber, Frank A.

In: Ethnicity and Disease, Vol. 15, No. 4, 01.09.2005, p. 568-577.

Research output: Contribution to journalArticle

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abstract = "Objective: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. Design, Setting, Participants: Healthy adolescents and young adults (N=413, 18.6 ± 2.8 yrs, 44{\%} Black, 53{\%} Male) drawn from a cardiovascular study. Main outcome measures: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARγ Pro12Ala, and TNFα -308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. Results: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/M2, 0.54 at BMI=40, P< .05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFα allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/L, P<.01). No effect of the PPARγ Pro12Ala polymorphism was found; the 12Ala PPARγ allele was rare among Blacks (2{\%}). Conclusions: The ApoB, TNFα, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7{\%}), may contribute to lower TG in Blacks. The -308A TNFα allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.",
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AU - Treiber, Frank A.

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N2 - Objective: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. Design, Setting, Participants: Healthy adolescents and young adults (N=413, 18.6 ± 2.8 yrs, 44% Black, 53% Male) drawn from a cardiovascular study. Main outcome measures: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARγ Pro12Ala, and TNFα -308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. Results: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/M2, 0.54 at BMI=40, P< .05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFα allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/L, P<.01). No effect of the PPARγ Pro12Ala polymorphism was found; the 12Ala PPARγ allele was rare among Blacks (2%). Conclusions: The ApoB, TNFα, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7%), may contribute to lower TG in Blacks. The -308A TNFα allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.

AB - Objective: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. Design, Setting, Participants: Healthy adolescents and young adults (N=413, 18.6 ± 2.8 yrs, 44% Black, 53% Male) drawn from a cardiovascular study. Main outcome measures: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARγ Pro12Ala, and TNFα -308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. Results: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/M2, 0.54 at BMI=40, P< .05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFα allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/L, P<.01). No effect of the PPARγ Pro12Ala polymorphism was found; the 12Ala PPARγ allele was rare among Blacks (2%). Conclusions: The ApoB, TNFα, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7%), may contribute to lower TG in Blacks. The -308A TNFα allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.

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KW - Cardiovascular

KW - Cholesterol

KW - Continental population groups

KW - HDL lipoproteins

KW - Polymorphism

KW - Risk factors

KW - Triglycerides

KW - Young adults

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