Genetic and molecular mechanisms of age regulation (homeostasis) of blood coagulation

Kotoku Kurachi, Kezhong Zhang, Afshin Ameri, Jeffery Huo, Hideko Atoda, Sumiko Kurachi

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Blood coagulation plays a critical role not only in hemostasis but also in many physiological and pathological conditions. Epidemiological studies have shown that blood coagulation capacity in humans increases with age. Towards understanding the underlying mechanisms, the age regulation of factor IX, a key blood coagulation factor, was extensively studied. A series of human factor IX minigenes, consisting of various components of the human factor IX gene, were constructed and subjected to systematic analyses with HepG2 cells in culture and over the entire life span of transgenic mice. These studies identified critical gene structures that are essential for the unique age-dependent expression patterns of the human factor IX gene - one acting by stabilizing gene transcription and another increasing the amount of mRNA present, presumably by augmenting mRNA stability. These studies have set the stage for analyzing the overall age-based regulatory mechanisms of blood coagulation.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalIUBMB Life
Volume49
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Aging
  • Cardiovascular disease
  • Factor IX
  • Hemophilia
  • Homeostasis
  • Thrombosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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