Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians

B R Achyut, N Moorchung, B Mittal

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

BACKGROUND: We evaluated the association of functional variants of IL-1 genes with the development of gastritis and precancerous lesions, which are known to be influenced by inflammatory response against Helicobacter pylori.

METHODS: After upper gastrointestinal (GI) endoscopy, 120 patients with gastritis were tested for H. pylori infection using rapid urease test, modified Giemsa staining and IgG anti-CagA ELISA. All patients and 243 healthy controls were genotyped for IL-1B (-511 C/T) and IL-IRN (VNTR) genes using PCR-RFLP/PCR.

RESULTS: IL-1B: (-511 C/T) genotype/allele were not associated with gastritis. IL-1RN 1/2 genotype carriers had susceptibility to gastritis (p=0.025, OR=1.7). Individuals with the IL-1RN 1/1 genotype (p=0.05, OR=0.65) and IL-1B -511*T-IL-1RN *1 haplotype were at low risk for gastritis (p=0.043, OR=0.72). High secretor haplotype combinations (C1-/T2+, C1-T1+ and T1+/T2+) did not influence neutrophilic infiltration, glandular atrophy or intestinal metaplasia.

CONCLUSIONS: We identified that individuals with the IL-1RN 1/2 genotype had increased risk for gastritis. IL-1B -511*T-IL-1RN *1 (T1) haplotype carriers were at decreased risk for gastritis and no significant association was observed for precancerous lesions in North Indians.

Original languageEnglish (US)
Pages (from-to)23-9
Number of pages7
JournalClinical and Experimental Medicine
Volume8
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Adult
  • Female
  • Gastritis
  • Haplotypes
  • Helicobacter pylori
  • Humans
  • Indians, North American
  • Interleukin-1beta
  • Male
  • Polymorphism, Genetic
  • Precancerous Conditions
  • Receptors, Interleukin-1
  • Journal Article
  • Research Support, Non-U.S. Gov't

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