Genetic influences on ambulatory blood pressure patterns. The Medical College of Virginia twin study

Grant W. Somes, Gregory A Harshfield, Bruce S. Alpert, Monica M. Goble, Richard M. Schicken

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The genetic influence of ambulatory blood pressure and heart rate was examined in 38 pairs of monozygotic twins, 17 pairs of same-sex dizygotic twins, and 11 pairs of opposite-sex dizygotic twins, all aged 15 or 17 years. The data were analyzed taking into consideration that the response was multivariate (24-h values) instead of the usual univariate response. The results demonstrated the heritability of ambulatory blood pressure and heart rate. This was true regardless of whether the estimate of heritability involved monozygotic twin pairs compared to same-sex dizygotic twin pairs only, or all dizygotic twin pairs. The time-related intraclass correlation coefficient within each twin classification indicated that the patterns of response within twin pairs correlated more for monozygotic twin pairs than within twin pairs for either set of dizygotic twin pairs. In addition, although the opposite-sex dizygotic twin pairs may have different mean levels of response, they exhibit a similarity of patterns of response akin to that seen within same-sex dizygotic twin pairs.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalAmerican journal of hypertension
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Ambulatory blood pressure
  • genetic influence on blood pressure
  • twin analysis

ASJC Scopus subject areas

  • Internal Medicine

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