TY - JOUR
T1 - Genetic influences on ambulatory blood pressure patterns. The Medical College of Virginia twin study
AU - Somes, Grant W.
AU - Harshfield, Gregory A.
AU - Alpert, Bruce S.
AU - Goble, Monica M.
AU - Schicken, Richard M.
N1 - Funding Information:
From the Department of Preventive Medicine (GWS), ment of Pediatrics (GAH, BSA), University of Tennessee, phis, Tennessee; Department of Pediatrics (MMG, RMS), College of Virginia, Richmond, Virginia. This research was supported by National Grants HL-35788 and GCRC MOI-RR0021. Address correspondence and reprint Somes, PhD, Department Preventive statistics and Epidemiology, 877 Madison 38163.
PY - 1995/5
Y1 - 1995/5
N2 - The genetic influence of ambulatory blood pressure and heart rate was examined in 38 pairs of monozygotic twins, 17 pairs of same-sex dizygotic twins, and 11 pairs of opposite-sex dizygotic twins, all aged 15 or 17 years. The data were analyzed taking into consideration that the response was multivariate (24-h values) instead of the usual univariate response. The results demonstrated the heritability of ambulatory blood pressure and heart rate. This was true regardless of whether the estimate of heritability involved monozygotic twin pairs compared to same-sex dizygotic twin pairs only, or all dizygotic twin pairs. The time-related intraclass correlation coefficient within each twin classification indicated that the patterns of response within twin pairs correlated more for monozygotic twin pairs than within twin pairs for either set of dizygotic twin pairs. In addition, although the opposite-sex dizygotic twin pairs may have different mean levels of response, they exhibit a similarity of patterns of response akin to that seen within same-sex dizygotic twin pairs.
AB - The genetic influence of ambulatory blood pressure and heart rate was examined in 38 pairs of monozygotic twins, 17 pairs of same-sex dizygotic twins, and 11 pairs of opposite-sex dizygotic twins, all aged 15 or 17 years. The data were analyzed taking into consideration that the response was multivariate (24-h values) instead of the usual univariate response. The results demonstrated the heritability of ambulatory blood pressure and heart rate. This was true regardless of whether the estimate of heritability involved monozygotic twin pairs compared to same-sex dizygotic twin pairs only, or all dizygotic twin pairs. The time-related intraclass correlation coefficient within each twin classification indicated that the patterns of response within twin pairs correlated more for monozygotic twin pairs than within twin pairs for either set of dizygotic twin pairs. In addition, although the opposite-sex dizygotic twin pairs may have different mean levels of response, they exhibit a similarity of patterns of response akin to that seen within same-sex dizygotic twin pairs.
KW - Ambulatory blood pressure
KW - genetic influence on blood pressure
KW - twin analysis
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U2 - 10.1016/0895-7061(95)00017-J
DO - 10.1016/0895-7061(95)00017-J
M3 - Article
C2 - 7662223
AN - SCOPUS:0029026165
VL - 8
SP - 474
EP - 478
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 5
ER -