Genetics and Genomics of Peripheral Arterial Disease

Ayotunde O. Dokun, Brian H. Annex

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.

Original languageEnglish (US)
Title of host publicationGenomic and Precision Medicine
Subtitle of host publicationCardiovascular Disease: Third Edition
PublisherElsevier Inc.
Pages197-219
Number of pages23
ISBN (Print)9780128018125
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

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Keywords

  • Gene association studies
  • Gene polymorphism
  • Gene therapy
  • Genome wide association studies
  • Genomic methodology
  • Haplotype
  • Linkage disequilibrium
  • Modifier gene
  • Peripheral arterial disease
  • Quantitative trait locus
  • Single nucleotide polymorphism
  • Therapeutic angiogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dokun, A. O., & Annex, B. H. (2018). Genetics and Genomics of Peripheral Arterial Disease. In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition (pp. 197-219). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801812-5.00007-X