TY - JOUR
T1 - Genetics in psychosomatic medicine
T2 - Research designs and statistical approaches
AU - McCaffery, Jeanne M.
AU - Snieder, Harold
AU - Dong, Yanbin
AU - De Geus, Eco
PY - 2007/2
Y1 - 2007/2
N2 - It has become increasingly clear that genetic factors influence many of the behaviors and disease endpoints of interest to psychosomatic medicine researchers. There has been increasing interest in incorporating genetic variation markers into psychosomatic research. In this Statistical Corner article, we build on the valuable experiences gained during two workshops for "starters in the field" at the American Psychosomatic Society and the Society for Psychophysiological Research to review two common genetically informative research designs for human studies: twin and genetic association studies. We outline statistical techniques for each and, for genetic association studies, address special topics, including the treatment of race and ethnicity, gene × gene and gene × environment interaction, haplotype analysis, and power and sample size. Finally, we discuss the issue of nonreplication and interpretation of results derived from genetic association studies. We hope this overview of twin and genetic association designs will support and stimulate thoughtful applications of genetic approaches within psychosomatic medicine.
AB - It has become increasingly clear that genetic factors influence many of the behaviors and disease endpoints of interest to psychosomatic medicine researchers. There has been increasing interest in incorporating genetic variation markers into psychosomatic research. In this Statistical Corner article, we build on the valuable experiences gained during two workshops for "starters in the field" at the American Psychosomatic Society and the Society for Psychophysiological Research to review two common genetically informative research designs for human studies: twin and genetic association studies. We outline statistical techniques for each and, for genetic association studies, address special topics, including the treatment of race and ethnicity, gene × gene and gene × environment interaction, haplotype analysis, and power and sample size. Finally, we discuss the issue of nonreplication and interpretation of results derived from genetic association studies. We hope this overview of twin and genetic association designs will support and stimulate thoughtful applications of genetic approaches within psychosomatic medicine.
KW - Genetics
KW - Statistics
KW - Twin studies
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U2 - 10.1097/PSY.0b013e31802f5dd4
DO - 10.1097/PSY.0b013e31802f5dd4
M3 - Review article
C2 - 17289826
AN - SCOPUS:33847737370
SN - 0033-3174
VL - 69
SP - 206
EP - 216
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
IS - 2
ER -