Genital ambiguity with a Y chromosome

Does gender assignment matter?

Christopher P. Houk, Jennifer Dayner, Peter A. Lee

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Recommendations for sex of rearing in newborns with genital ambiguity, testicular differentiation and a Y chromosome continue to be challenging. Complaints from former patients have forced those providing the medical, surgical and psychological care for these individuals to reassess evaluation and treatment strategies. In this paper, the histories of six patients born with genital ambiguity and at least partial testicular differentiation with a karyotype containing a Y chromosome are presented. Three of these patients were assigned as males and three as females. The factors involved in these individuals' adaptation to the assigned gender and their subsequent quality of life are discussed. Factors needing further study, including the parents' ability to accept and support the sex of rearing, the child's temperament, associated psychological disorders, and other influences, such as masculinization of the central nervous system, are highlighted.

Original languageEnglish (US)
Pages (from-to)825-839
Number of pages15
JournalJournal of Pediatric Endocrinology and Metabolism
Volume17
Issue number6
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Disorders of Sex Development
Y Chromosome
Psychology
Child Rearing
Aptitude
Temperament
Karyotype
Central Nervous System
Parents
Quality of Life
Newborn Infant
Therapeutics

Keywords

  • Genital ambiguity
  • Intersex
  • Male pseudohermaphroditism
  • Mixed gonadal dysgenesis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Genital ambiguity with a Y chromosome : Does gender assignment matter? / Houk, Christopher P.; Dayner, Jennifer; Lee, Peter A.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 17, No. 6, 01.01.2004, p. 825-839.

Research output: Contribution to journalReview article

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