Genome wide association scan for chronic periodontitis implicates novel locus

Ping Feng, Xiaojing Wang, Priscila L. Casado, Erika C. Küchler, Kathleen Deeley, Jacqueline Noel, Hyongsup Kimm, Ji Hye Kim, Alex N. Haas, Valquiria Quinelato, Leticia L. Bonato, Jose M. Granjeiro, Cristiano Susin, Alexandre R. Vieira

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).Methods: Genotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.Results: The rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.Conclusions: Our data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis.

Original languageEnglish (US)
Article number84
JournalBMC Oral Health
Volume14
Issue number1
DOIs
Publication statusPublished - Jul 9 2014

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Keywords

  • Aggressive periodontitis
  • Chronic periodontitis
  • Genetic polymorphism
  • Genetics
  • Medical genetics
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Feng, P., Wang, X., Casado, P. L., Küchler, E. C., Deeley, K., Noel, J., ... Vieira, A. R. (2014). Genome wide association scan for chronic periodontitis implicates novel locus. BMC Oral Health, 14(1), [84]. https://doi.org/10.1186/1472-6831-14-84