Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

Wei Hua Yue, Hai Feng Wang, Liang Dan Sun, Fulei Tang, Zhong Hua Liu, Hong Xing Zhang, Wen Qiang Li, Yan Ling Zhang, Yang Zhang, Cui Cui Ma, Bo Du, Li Fang Wang, Yun Qing Ren, Yong Feng Yang, Xiao Feng Hu, Yi Wang, Wei Deng, Li Wen Tan, Yun Long Tan, Qi ChenGuang Ming Xu, Gui Gang Yang, Xian Bo Zuo, Hao Yan, Yan Yan Ruan, Tian Lan Lu, Xue Han, Xiao Hong Ma, Yan Wang, Li Wei Cai, Chao Jin, Hong Yan Zhang, Jun Yan, Wei Feng Mi, Xian Yong Yin, Wen Bin Ma, Qi Liu, Lan Kang, Wei Sun, Cheng Ying Pan, Mei Shuang, Fu De Yang, Chuan Yue Wang, Jian Li Yang, Ke Qing Li, Xin Ma, Ling Jiang Li, Xin Yu, Qi Zhai Li, Xun Huang, Lu Xian Lv, Tao Li, Guo Ping Zhao, Wei Huang, Xue Jun Zhang, Dai Zhang

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189 Scopus citations

Abstract

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P combined = 4.76 × 10 -11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P combined = 6.91 × 10 -12, OR = 0.78; rs2142731 in an intron of PGBD1, P combined = 5.14 × 10 -10, OR = 0.79) and 11p11.2 (rs11038167 near the 5ĝ€2 UTR of TSPAN18, P combined = 1.09 × 10 -11, OR = 1.29; rs11038172, P combined = 7.21 × 10 -10, OR = 1.25; rs835784, P combined = 2.73 × 10 -11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

Original languageEnglish (US)
Pages (from-to)1228-1231
Number of pages4
JournalNature Genetics
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Yue, W. H., Wang, H. F., Sun, L. D., Tang, F., Liu, Z. H., Zhang, H. X., Li, W. Q., Zhang, Y. L., Zhang, Y., Ma, C. C., Du, B., Wang, L. F., Ren, Y. Q., Yang, Y. F., Hu, X. F., Wang, Y., Deng, W., Tan, L. W., Tan, Y. L., ... Zhang, D. (2011). Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics, 43(12), 1228-1231. https://doi.org/10.1038/ng.979