Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

Wei Hua Yue; Hai Feng Wang; Liang Dan Sun; Fulei Tang; Zhong Hua Liu; Hong Xing Zhang; Wen Qiang Li; Yan Ling Zhang; Yang Zhang; Cui Cui Ma; Bo Du; Li Fang Wang; Yun Qing Ren; Yong Feng Yang; Xiao Feng Hu; Yi Wang; Wei Deng; Li Wen Tan; Yun Long Tan; Qi Chen; Guang Ming Xu; Gui Gang Yang; Xian Bo Zuo; Hao Yan; Yan Yan Ruan; Tian Lan Lu; Xue Han; Xiao Hong Ma; Yan Wang; Li Wei Cai; Chao Jin; Hong Yan Zhang; Jun Yan; Wei Feng Mi; Xian Yong Yin; Wen Bin Ma; Qi Liu; Lan Kang; Wei Sun; Cheng Ying Pan; Mei Shuang; Fu De Yang; Chuan Yue Wang; Jian Li Yang; Ke Qing Li; Xin Ma; Ling Jiang Li; Xin Yu; Qi Zhai Li; Xun Huang; Lu Xian Lv; Tao Li; Guo Ping Zhao; Wei Huang; Xue Jun Zhang; Dai Zhang

doi:10.1038/ng.979

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

Wei Hua Yue, Hai Feng Wang, Liang Dan Sun, Fulei Tang, Zhong Hua Liu, Hong Xing Zhang, Wen Qiang Li, Yan Ling Zhang, Yang Zhang, Cui Cui Ma, Bo Du, Li Fang Wang, Yun Qing Ren, Yong Feng Yang, Xiao Feng Hu, Yi Wang, Wei Deng, Li Wen Tan, Yun Long Tan, Qi ChenGuang Ming Xu, Gui Gang Yang, Xian Bo Zuo, Hao Yan, Yan Yan Ruan, Tian Lan Lu, Xue Han, Xiao Hong Ma, Yan Wang, Li Wei Cai, Chao Jin, Hong Yan Zhang, Jun Yan, Wei Feng Mi, Xian Yong Yin, Wen Bin Ma, Qi Liu, Lan Kang, Wei Sun, Cheng Ying Pan, Mei Shuang, Fu De Yang, Chuan Yue Wang, Jian Li Yang, Ke Qing Li, Xin Ma, Ling Jiang Li, Xin Yu, Qi Zhai Li, Xun Huang, Lu Xian Lv, Tao Li, Guo Ping Zhao, Wei Huang, Xue Jun Zhang, Dai Zhang

Research output: Contribution to journal › Article › peer-review

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Abstract

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P _combined = 4.76 × 10 ^-11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P _combined = 6.91 × 10 ^-12, OR = 0.78; rs2142731 in an intron of PGBD1, P _combined = 5.14 × 10 ^-10, OR = 0.79) and 11p11.2 (rs11038167 near the 5ĝ€2 UTR of TSPAN18, P _combined = 1.09 × 10 ^-11, OR = 1.29; rs11038172, P _combined = 7.21 × 10 ^-10, OR = 1.25; rs835784, P _combined = 2.73 × 10 ^-11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

Original language	English (US)
Pages (from-to)	1228-1231
Number of pages	4
Journal	Nature Genetics
Volume	43
Issue number	12
DOIs	https://doi.org/10.1038/ng.979
State	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng.979

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Yue, W. H., Wang, H. F., Sun, L. D., Tang, F., Liu, Z. H., Zhang, H. X., Li, W. Q., Zhang, Y. L., Zhang, Y., Ma, C. C., Du, B., Wang, L. F., Ren, Y. Q., Yang, Y. F., Hu, X. F., Wang, Y., Deng, W., Tan, L. W., Tan, Y. L., ... Zhang, D. (2011). Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics, 43(12), 1228-1231. https://doi.org/10.1038/ng.979

Yue, WH, Wang, HF, Sun, LD, Tang, F, Liu, ZH, Zhang, HX, Li, WQ, Zhang, YL, Zhang, Y, Ma, CC, Du, B, Wang, LF, Ren, YQ, Yang, YF, Hu, XF, Wang, Y, Deng, W, Tan, LW, Tan, YL, Chen, Q, Xu, GM, Yang, GG, Zuo, XB, Yan, H, Ruan, YY, Lu, TL, Han, X, Ma, XH, Wang, Y, Cai, LW, Jin, C, Zhang, HY, Yan, J, Mi, WF, Yin, XY, Ma, WB, Liu, Q, Kang, L, Sun, W, Pan, CY, Shuang, M, Yang, FD, Wang, CY, Yang, JL, Li, KQ, Ma, X, Li, LJ, Yu, X, Li, QZ, Huang, X, Lv, LX, Li, T, Zhao, GP, Huang, W, Zhang, XJ & Zhang, D 2011, 'Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2', Nature Genetics, vol. 43, no. 12, pp. 1228-1231. https://doi.org/10.1038/ng.979

@article{7b3608696f324fa484ac0c10a7b62ae8,

title = "Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2",

abstract = "To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P combined = 4.76 × 10 -11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P combined = 6.91 × 10 -12, OR = 0.78; rs2142731 in an intron of PGBD1, P combined = 5.14 × 10 -10, OR = 0.79) and 11p11.2 (rs11038167 near the 5ĝ€2 UTR of TSPAN18, P combined = 1.09 × 10 -11, OR = 1.29; rs11038172, P combined = 7.21 × 10 -10, OR = 1.25; rs835784, P combined = 2.73 × 10 -11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.",

author = "Yue, {Wei Hua} and Wang, {Hai Feng} and Sun, {Liang Dan} and Fulei Tang and Liu, {Zhong Hua} and Zhang, {Hong Xing} and Li, {Wen Qiang} and Zhang, {Yan Ling} and Yang Zhang and Ma, {Cui Cui} and Bo Du and Wang, {Li Fang} and Ren, {Yun Qing} and Yang, {Yong Feng} and Hu, {Xiao Feng} and Yi Wang and Wei Deng and Tan, {Li Wen} and Tan, {Yun Long} and Qi Chen and Xu, {Guang Ming} and Yang, {Gui Gang} and Zuo, {Xian Bo} and Hao Yan and Ruan, {Yan Yan} and Lu, {Tian Lan} and Xue Han and Ma, {Xiao Hong} and Yan Wang and Cai, {Li Wei} and Chao Jin and Zhang, {Hong Yan} and Jun Yan and Mi, {Wei Feng} and Yin, {Xian Yong} and Ma, {Wen Bin} and Qi Liu and Lan Kang and Wei Sun and Pan, {Cheng Ying} and Mei Shuang and Yang, {Fu De} and Wang, {Chuan Yue} and Yang, {Jian Li} and Li, {Ke Qing} and Xin Ma and Li, {Ling Jiang} and Xin Yu and Li, {Qi Zhai} and Xun Huang and Lv, {Lu Xian} and Tao Li and Zhao, {Guo Ping} and Wei Huang and Zhang, {Xue Jun} and Dai Zhang",

note = "Funding Information: We thank J. Liu from the Human Genetics, Genome Institute of Singapore for his suggestions for revision of the manuscript. We acknowledge with appreciation all the individuals with schizophrenia and healthy control subjects whose contributions made this work possible. This work was supported by research grants from the National High-Tech Research and Development Program of China (2009AA022702), the National Natural Science Foundation of China (30530290, 30870896, 81071087 and 81071088), the National Basic Research Program of China (2007CB512301, 2011CB707805) and the International Science & Technology Cooperation Program of China (2010DFB30820).",

year = "2011",

month = dec,

doi = "10.1038/ng.979",

language = "English (US)",

volume = "43",

pages = "1228--1231",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

AU - Yue, Wei Hua

AU - Wang, Hai Feng

AU - Sun, Liang Dan

AU - Tang, Fulei

AU - Liu, Zhong Hua

AU - Zhang, Hong Xing

AU - Li, Wen Qiang

AU - Zhang, Yan Ling

AU - Zhang, Yang

AU - Ma, Cui Cui

AU - Du, Bo

AU - Wang, Li Fang

AU - Ren, Yun Qing

AU - Yang, Yong Feng

AU - Hu, Xiao Feng

AU - Wang, Yi

AU - Deng, Wei

AU - Tan, Li Wen

AU - Tan, Yun Long

AU - Chen, Qi

AU - Xu, Guang Ming

AU - Yang, Gui Gang

AU - Zuo, Xian Bo

AU - Yan, Hao

AU - Ruan, Yan Yan

AU - Lu, Tian Lan

AU - Han, Xue

AU - Ma, Xiao Hong

AU - Wang, Yan

AU - Cai, Li Wei

AU - Jin, Chao

AU - Zhang, Hong Yan

AU - Yan, Jun

AU - Mi, Wei Feng

AU - Yin, Xian Yong

AU - Ma, Wen Bin

AU - Liu, Qi

AU - Kang, Lan

AU - Sun, Wei

AU - Pan, Cheng Ying

AU - Shuang, Mei

AU - Yang, Fu De

AU - Wang, Chuan Yue

AU - Yang, Jian Li

AU - Li, Ke Qing

AU - Ma, Xin

AU - Li, Ling Jiang

AU - Yu, Xin

AU - Li, Qi Zhai

AU - Huang, Xun

AU - Lv, Lu Xian

AU - Li, Tao

AU - Zhao, Guo Ping

AU - Huang, Wei

AU - Zhang, Xue Jun

AU - Zhang, Dai

N1 - Funding Information: We thank J. Liu from the Human Genetics, Genome Institute of Singapore for his suggestions for revision of the manuscript. We acknowledge with appreciation all the individuals with schizophrenia and healthy control subjects whose contributions made this work possible. This work was supported by research grants from the National High-Tech Research and Development Program of China (2009AA022702), the National Natural Science Foundation of China (30530290, 30870896, 81071087 and 81071088), the National Basic Research Program of China (2007CB512301, 2011CB707805) and the International Science & Technology Cooperation Program of China (2010DFB30820).

PY - 2011/12

Y1 - 2011/12

N2 - To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P combined = 4.76 × 10 -11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P combined = 6.91 × 10 -12, OR = 0.78; rs2142731 in an intron of PGBD1, P combined = 5.14 × 10 -10, OR = 0.79) and 11p11.2 (rs11038167 near the 5ĝ€2 UTR of TSPAN18, P combined = 1.09 × 10 -11, OR = 1.29; rs11038172, P combined = 7.21 × 10 -10, OR = 1.25; rs835784, P combined = 2.73 × 10 -11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

AB - To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P combined = 4.76 × 10 -11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P combined = 6.91 × 10 -12, OR = 0.78; rs2142731 in an intron of PGBD1, P combined = 5.14 × 10 -10, OR = 0.79) and 11p11.2 (rs11038167 near the 5ĝ€2 UTR of TSPAN18, P combined = 1.09 × 10 -11, OR = 1.29; rs11038172, P combined = 7.21 × 10 -10, OR = 1.25; rs835784, P combined = 2.73 × 10 -11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

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JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

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