Genome-wide gene expression profiles of the developing mouse hippocampus

Monica Mody, Yanxiang Cao, Zhenzhong Cui, Khoon Yen Tay, Andy Shyong, Eiji Shimizu, Kelvin Pham, Peter Schultz, Douglas Welsh, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.

Original languageEnglish (US)
Pages (from-to)8862-8867
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number15
DOIs
StatePublished - Jul 17 2001

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Transcriptome
Hippocampus
Genome
Genes
Expressed Sequence Tags
Multigene Family
Oligonucleotide Array Sequence Analysis
Synapses
Embryonic Development
Cluster Analysis
Molecular Biology
Learning
Databases
Brain

ASJC Scopus subject areas

  • General

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Genome-wide gene expression profiles of the developing mouse hippocampus. / Mody, Monica; Cao, Yanxiang; Cui, Zhenzhong; Tay, Khoon Yen; Shyong, Andy; Shimizu, Eiji; Pham, Kelvin; Schultz, Peter; Welsh, Douglas; Tsien, Joseph Zhuo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 15, 17.07.2001, p. 8862-8867.

Research output: Contribution to journalArticle

Mody, Monica ; Cao, Yanxiang ; Cui, Zhenzhong ; Tay, Khoon Yen ; Shyong, Andy ; Shimizu, Eiji ; Pham, Kelvin ; Schultz, Peter ; Welsh, Douglas ; Tsien, Joseph Zhuo. / Genome-wide gene expression profiles of the developing mouse hippocampus. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 15. pp. 8862-8867.
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AU - Pham, Kelvin

AU - Schultz, Peter

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