Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005

M. A. Pfaller, D. J. Diekema, D. L. Gibbs, V. A. Newell, K. P. Ng, A. Colombo, J. Finquelievich, R. Barnes, J. Wadula, Jorge Finquelievich, Nora Tiraboschi, David Ellis, Dominique Fameree, Anne Marie van den Abeele, Jean Marc Senterre, Arnaldo Lopez Colombo, Robert Rennie, Stephen Sanche, Hu Bijie, Yingchun XuWang Fu, Nan Shan Zhong, Pilar Rivas, Catalina de Bedout, Matilde Mendez, Ricardo Vega, Nada Mallatova, Stanislava Dobiasova, Julio Ayabaca, Jeannete Zurita, M. Mallie, E. Candolfi, W. Fegeler, P. D.G. Haase, A. Rodloff, W. Bar, V. Czaika, George Petrikos, Erzsébet Puskás, Ilona Dóczi, Gyula Mestyan, Radka Nikolova, Uma Banerjee, Nathan Keller, Vivian Tullio, Gian Carlo Schito, Domenico D'Antonio, Pietro Martino, N. G. Kee Peng, Celia Alpuche, Jose Santos, Rayo Morfin Ortero, Mussaret Zaidi, Jacques F. Meis, Egil Lingaas, Danuta Dzierzanowska, Waclaw Pawliszyn, Mariada Luz Martins, Luis Albuquerque, Laura Rosado, Rosa Velho, Jose Amorim, Vera N. Ilina, Olga I. Kretchikova, Galina A. Klyasova, Sophia M. Rozanova, Irina G. Multykh, Nikolay N. Klimko, Elena D. Agapova, Natalya V. Dmitrieva, Abdul Mohsen Al-Rasheed, Atef Shibl, Jan Trupl, Hupkova Helena, Anwar Hoosen, Jeannette Wadula, M. N. Janse van Rensburg, Adriano Duse, Kyungwon Lee, Mi Na Kim, A. del Palacio, Aurora Sanchez-Sousa, Jacques Bille, K. Muhlethaler, Shan Chwen Chang, Jen Hsien Wang, Deniz Gur, Volkan Korten, John Paul, Derek Brown, Chris Kibbler, Nigel Weightman, Ian M. Gould, Claire Rennison, Richard Barton, Rosemary Barnes, Jose Vazquez, Davise Larone, Mike Rinaldi, Heidi Reyes, Axel Santiago

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

We examined data from the ARTEMIS DISK Antifungal Surveillance Program to describe geographic and temporal trends in the isolation of Candida parapsilosis from clinical specimens and the in vitro susceptibilities of 9,371 isolates to fluconazole and voriconazole. We also report the in vitro susceptibility of bloodstream infection (BSI) isolates of C. parapsilosis to the echinocandins, anidulafungin, caspofungin, and micafungin. C. parapsilosis represented 6.6% of the 141,383 isolates of Candida collected from 2001 to 2005 and was most common among isolates from North America (14.3%) and Latin America (9.9%). High levels of susceptibility to both fluconazole (90.8 to 95.8%) and voriconazole (95.3 to 98.1%) were observed in all geographic regions with the exception of the Africa and Middle East region (79.3 and 85.8% susceptible to fluconazole and voriconazole, respectively). C. parapsilosis was most often isolated from blood and skin and/or soft tissue specimens and from patients hospitalized in the medical, surgical, intensive care unit (ICU) and dermatology services. Notably, isolates from the surgical ICU were the least susceptible to fluconazole (86.3%). There was no evidence of increasing azole resistance over time among C. parapsilosis isolates tested from 2001 to 2005. Of BSI isolates tested against the three echinocandins, 92, 99, and 100% were inhibited by concentrations of ≤2 μg/ml of anidulafungin (621 isolates tested), caspofungin (1,447 isolates tested), and micafungin (539 isolates tested), respectively. C. parapsilosis is a ubiquitous pathogen that remains susceptible to the azoles and echinocandins; however, both the frequency of isolation and the resistance of C. parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service.

Original languageEnglish (US)
Pages (from-to)842-849
Number of pages8
JournalJournal of clinical microbiology
Volume46
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Fluconazole
Candida
Echinocandins
caspofungin
anidulafungin
Azoles
Critical Care
Intensive Care Units
Middle East
Latin America
North America
Dermatology
Infection
Skin
Voriconazole
In Vitro Techniques
micafungin

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis : A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005. / Pfaller, M. A.; Diekema, D. J.; Gibbs, D. L.; Newell, V. A.; Ng, K. P.; Colombo, A.; Finquelievich, J.; Barnes, R.; Wadula, J.; Finquelievich, Jorge; Tiraboschi, Nora; Ellis, David; Fameree, Dominique; van den Abeele, Anne Marie; Senterre, Jean Marc; Lopez Colombo, Arnaldo; Rennie, Robert; Sanche, Stephen; Bijie, Hu; Xu, Yingchun; Fu, Wang; Zhong, Nan Shan; Rivas, Pilar; de Bedout, Catalina; Mendez, Matilde; Vega, Ricardo; Mallatova, Nada; Dobiasova, Stanislava; Ayabaca, Julio; Zurita, Jeannete; Mallie, M.; Candolfi, E.; Fegeler, W.; Haase, P. D.G.; Rodloff, A.; Bar, W.; Czaika, V.; Petrikos, George; Puskás, Erzsébet; Dóczi, Ilona; Mestyan, Gyula; Nikolova, Radka; Banerjee, Uma; Keller, Nathan; Tullio, Vivian; Carlo Schito, Gian; D'Antonio, Domenico; Martino, Pietro; Kee Peng, N. G.; Alpuche, Celia; Santos, Jose; Morfin Ortero, Rayo; Zaidi, Mussaret; Meis, Jacques F.; Lingaas, Egil; Dzierzanowska, Danuta; Pawliszyn, Waclaw; Luz Martins, Mariada; Albuquerque, Luis; Rosado, Laura; Velho, Rosa; Amorim, Jose; Ilina, Vera N.; Kretchikova, Olga I.; Klyasova, Galina A.; Rozanova, Sophia M.; Multykh, Irina G.; Klimko, Nikolay N.; Agapova, Elena D.; Dmitrieva, Natalya V.; Al-Rasheed, Abdul Mohsen; Shibl, Atef; Trupl, Jan; Helena, Hupkova; Hoosen, Anwar; Wadula, Jeannette; Janse van Rensburg, M. N.; Duse, Adriano; Lee, Kyungwon; Kim, Mi Na; del Palacio, A.; Sanchez-Sousa, Aurora; Bille, Jacques; Muhlethaler, K.; Chang, Shan Chwen; Wang, Jen Hsien; Gur, Deniz; Korten, Volkan; Paul, John; Brown, Derek; Kibbler, Chris; Weightman, Nigel; Gould, Ian M.; Rennison, Claire; Barton, Richard; Barnes, Rosemary; Vazquez, Jose; Larone, Davise; Rinaldi, Mike; Reyes, Heidi; Santiago, Axel.

In: Journal of clinical microbiology, Vol. 46, No. 3, 01.03.2008, p. 842-849.

Research output: Contribution to journalArticle

Pfaller, MA, Diekema, DJ, Gibbs, DL, Newell, VA, Ng, KP, Colombo, A, Finquelievich, J, Barnes, R, Wadula, J, Finquelievich, J, Tiraboschi, N, Ellis, D, Fameree, D, van den Abeele, AM, Senterre, JM, Lopez Colombo, A, Rennie, R, Sanche, S, Bijie, H, Xu, Y, Fu, W, Zhong, NS, Rivas, P, de Bedout, C, Mendez, M, Vega, R, Mallatova, N, Dobiasova, S, Ayabaca, J, Zurita, J, Mallie, M, Candolfi, E, Fegeler, W, Haase, PDG, Rodloff, A, Bar, W, Czaika, V, Petrikos, G, Puskás, E, Dóczi, I, Mestyan, G, Nikolova, R, Banerjee, U, Keller, N, Tullio, V, Carlo Schito, G, D'Antonio, D, Martino, P, Kee Peng, NG, Alpuche, C, Santos, J, Morfin Ortero, R, Zaidi, M, Meis, JF, Lingaas, E, Dzierzanowska, D, Pawliszyn, W, Luz Martins, M, Albuquerque, L, Rosado, L, Velho, R, Amorim, J, Ilina, VN, Kretchikova, OI, Klyasova, GA, Rozanova, SM, Multykh, IG, Klimko, NN, Agapova, ED, Dmitrieva, NV, Al-Rasheed, AM, Shibl, A, Trupl, J, Helena, H, Hoosen, A, Wadula, J, Janse van Rensburg, MN, Duse, A, Lee, K, Kim, MN, del Palacio, A, Sanchez-Sousa, A, Bille, J, Muhlethaler, K, Chang, SC, Wang, JH, Gur, D, Korten, V, Paul, J, Brown, D, Kibbler, C, Weightman, N, Gould, IM, Rennison, C, Barton, R, Barnes, R, Vazquez, J, Larone, D, Rinaldi, M, Reyes, H & Santiago, A 2008, 'Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005', Journal of clinical microbiology, vol. 46, no. 3, pp. 842-849. https://doi.org/10.1128/JCM.02122-07
Pfaller, M. A. ; Diekema, D. J. ; Gibbs, D. L. ; Newell, V. A. ; Ng, K. P. ; Colombo, A. ; Finquelievich, J. ; Barnes, R. ; Wadula, J. ; Finquelievich, Jorge ; Tiraboschi, Nora ; Ellis, David ; Fameree, Dominique ; van den Abeele, Anne Marie ; Senterre, Jean Marc ; Lopez Colombo, Arnaldo ; Rennie, Robert ; Sanche, Stephen ; Bijie, Hu ; Xu, Yingchun ; Fu, Wang ; Zhong, Nan Shan ; Rivas, Pilar ; de Bedout, Catalina ; Mendez, Matilde ; Vega, Ricardo ; Mallatova, Nada ; Dobiasova, Stanislava ; Ayabaca, Julio ; Zurita, Jeannete ; Mallie, M. ; Candolfi, E. ; Fegeler, W. ; Haase, P. D.G. ; Rodloff, A. ; Bar, W. ; Czaika, V. ; Petrikos, George ; Puskás, Erzsébet ; Dóczi, Ilona ; Mestyan, Gyula ; Nikolova, Radka ; Banerjee, Uma ; Keller, Nathan ; Tullio, Vivian ; Carlo Schito, Gian ; D'Antonio, Domenico ; Martino, Pietro ; Kee Peng, N. G. ; Alpuche, Celia ; Santos, Jose ; Morfin Ortero, Rayo ; Zaidi, Mussaret ; Meis, Jacques F. ; Lingaas, Egil ; Dzierzanowska, Danuta ; Pawliszyn, Waclaw ; Luz Martins, Mariada ; Albuquerque, Luis ; Rosado, Laura ; Velho, Rosa ; Amorim, Jose ; Ilina, Vera N. ; Kretchikova, Olga I. ; Klyasova, Galina A. ; Rozanova, Sophia M. ; Multykh, Irina G. ; Klimko, Nikolay N. ; Agapova, Elena D. ; Dmitrieva, Natalya V. ; Al-Rasheed, Abdul Mohsen ; Shibl, Atef ; Trupl, Jan ; Helena, Hupkova ; Hoosen, Anwar ; Wadula, Jeannette ; Janse van Rensburg, M. N. ; Duse, Adriano ; Lee, Kyungwon ; Kim, Mi Na ; del Palacio, A. ; Sanchez-Sousa, Aurora ; Bille, Jacques ; Muhlethaler, K. ; Chang, Shan Chwen ; Wang, Jen Hsien ; Gur, Deniz ; Korten, Volkan ; Paul, John ; Brown, Derek ; Kibbler, Chris ; Weightman, Nigel ; Gould, Ian M. ; Rennison, Claire ; Barton, Richard ; Barnes, Rosemary ; Vazquez, Jose ; Larone, Davise ; Rinaldi, Mike ; Reyes, Heidi ; Santiago, Axel. / Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis : A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005. In: Journal of clinical microbiology. 2008 ; Vol. 46, No. 3. pp. 842-849.
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abstract = "We examined data from the ARTEMIS DISK Antifungal Surveillance Program to describe geographic and temporal trends in the isolation of Candida parapsilosis from clinical specimens and the in vitro susceptibilities of 9,371 isolates to fluconazole and voriconazole. We also report the in vitro susceptibility of bloodstream infection (BSI) isolates of C. parapsilosis to the echinocandins, anidulafungin, caspofungin, and micafungin. C. parapsilosis represented 6.6{\%} of the 141,383 isolates of Candida collected from 2001 to 2005 and was most common among isolates from North America (14.3{\%}) and Latin America (9.9{\%}). High levels of susceptibility to both fluconazole (90.8 to 95.8{\%}) and voriconazole (95.3 to 98.1{\%}) were observed in all geographic regions with the exception of the Africa and Middle East region (79.3 and 85.8{\%} susceptible to fluconazole and voriconazole, respectively). C. parapsilosis was most often isolated from blood and skin and/or soft tissue specimens and from patients hospitalized in the medical, surgical, intensive care unit (ICU) and dermatology services. Notably, isolates from the surgical ICU were the least susceptible to fluconazole (86.3{\%}). There was no evidence of increasing azole resistance over time among C. parapsilosis isolates tested from 2001 to 2005. Of BSI isolates tested against the three echinocandins, 92, 99, and 100{\%} were inhibited by concentrations of ≤2 μg/ml of anidulafungin (621 isolates tested), caspofungin (1,447 isolates tested), and micafungin (539 isolates tested), respectively. C. parapsilosis is a ubiquitous pathogen that remains susceptible to the azoles and echinocandins; however, both the frequency of isolation and the resistance of C. parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service.",
author = "Pfaller, {M. A.} and Diekema, {D. J.} and Gibbs, {D. L.} and Newell, {V. A.} and Ng, {K. P.} and A. Colombo and J. Finquelievich and R. Barnes and J. Wadula and Jorge Finquelievich and Nora Tiraboschi and David Ellis and Dominique Fameree and {van den Abeele}, {Anne Marie} and Senterre, {Jean Marc} and {Lopez Colombo}, Arnaldo and Robert Rennie and Stephen Sanche and Hu Bijie and Yingchun Xu and Wang Fu and Zhong, {Nan Shan} and Pilar Rivas and {de Bedout}, Catalina and Matilde Mendez and Ricardo Vega and Nada Mallatova and Stanislava Dobiasova and Julio Ayabaca and Jeannete Zurita and M. Mallie and E. Candolfi and W. Fegeler and Haase, {P. D.G.} and A. Rodloff and W. Bar and V. Czaika and George Petrikos and Erzs{\'e}bet Pusk{\'a}s and Ilona D{\'o}czi and Gyula Mestyan and Radka Nikolova and Uma Banerjee and Nathan Keller and Vivian Tullio and {Carlo Schito}, Gian and Domenico D'Antonio and Pietro Martino and {Kee Peng}, {N. G.} and Celia Alpuche and Jose Santos and {Morfin Ortero}, Rayo and Mussaret Zaidi and Meis, {Jacques F.} and Egil Lingaas and Danuta Dzierzanowska and Waclaw Pawliszyn and {Luz Martins}, Mariada and Luis Albuquerque and Laura Rosado and Rosa Velho and Jose Amorim and Ilina, {Vera N.} and Kretchikova, {Olga I.} and Klyasova, {Galina A.} and Rozanova, {Sophia M.} and Multykh, {Irina G.} and Klimko, {Nikolay N.} and Agapova, {Elena D.} and Dmitrieva, {Natalya V.} and Al-Rasheed, {Abdul Mohsen} and Atef Shibl and Jan Trupl and Hupkova Helena and Anwar Hoosen and Jeannette Wadula and {Janse van Rensburg}, {M. N.} and Adriano Duse and Kyungwon Lee and Kim, {Mi Na} and {del Palacio}, A. and Aurora Sanchez-Sousa and Jacques Bille and K. Muhlethaler and Chang, {Shan Chwen} and Wang, {Jen Hsien} and Deniz Gur and Volkan Korten and John Paul and Derek Brown and Chris Kibbler and Nigel Weightman and Gould, {Ian M.} and Claire Rennison and Richard Barton and Rosemary Barnes and Jose Vazquez and Davise Larone and Mike Rinaldi and Heidi Reyes and Axel Santiago",
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language = "English (US)",
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TY - JOUR

T1 - Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis

T2 - A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005

AU - Pfaller, M. A.

AU - Diekema, D. J.

AU - Gibbs, D. L.

AU - Newell, V. A.

AU - Ng, K. P.

AU - Colombo, A.

AU - Finquelievich, J.

AU - Barnes, R.

AU - Wadula, J.

AU - Finquelievich, Jorge

AU - Tiraboschi, Nora

AU - Ellis, David

AU - Fameree, Dominique

AU - van den Abeele, Anne Marie

AU - Senterre, Jean Marc

AU - Lopez Colombo, Arnaldo

AU - Rennie, Robert

AU - Sanche, Stephen

AU - Bijie, Hu

AU - Xu, Yingchun

AU - Fu, Wang

AU - Zhong, Nan Shan

AU - Rivas, Pilar

AU - de Bedout, Catalina

AU - Mendez, Matilde

AU - Vega, Ricardo

AU - Mallatova, Nada

AU - Dobiasova, Stanislava

AU - Ayabaca, Julio

AU - Zurita, Jeannete

AU - Mallie, M.

AU - Candolfi, E.

AU - Fegeler, W.

AU - Haase, P. D.G.

AU - Rodloff, A.

AU - Bar, W.

AU - Czaika, V.

AU - Petrikos, George

AU - Puskás, Erzsébet

AU - Dóczi, Ilona

AU - Mestyan, Gyula

AU - Nikolova, Radka

AU - Banerjee, Uma

AU - Keller, Nathan

AU - Tullio, Vivian

AU - Carlo Schito, Gian

AU - D'Antonio, Domenico

AU - Martino, Pietro

AU - Kee Peng, N. G.

AU - Alpuche, Celia

AU - Santos, Jose

AU - Morfin Ortero, Rayo

AU - Zaidi, Mussaret

AU - Meis, Jacques F.

AU - Lingaas, Egil

AU - Dzierzanowska, Danuta

AU - Pawliszyn, Waclaw

AU - Luz Martins, Mariada

AU - Albuquerque, Luis

AU - Rosado, Laura

AU - Velho, Rosa

AU - Amorim, Jose

AU - Ilina, Vera N.

AU - Kretchikova, Olga I.

AU - Klyasova, Galina A.

AU - Rozanova, Sophia M.

AU - Multykh, Irina G.

AU - Klimko, Nikolay N.

AU - Agapova, Elena D.

AU - Dmitrieva, Natalya V.

AU - Al-Rasheed, Abdul Mohsen

AU - Shibl, Atef

AU - Trupl, Jan

AU - Helena, Hupkova

AU - Hoosen, Anwar

AU - Wadula, Jeannette

AU - Janse van Rensburg, M. N.

AU - Duse, Adriano

AU - Lee, Kyungwon

AU - Kim, Mi Na

AU - del Palacio, A.

AU - Sanchez-Sousa, Aurora

AU - Bille, Jacques

AU - Muhlethaler, K.

AU - Chang, Shan Chwen

AU - Wang, Jen Hsien

AU - Gur, Deniz

AU - Korten, Volkan

AU - Paul, John

AU - Brown, Derek

AU - Kibbler, Chris

AU - Weightman, Nigel

AU - Gould, Ian M.

AU - Rennison, Claire

AU - Barton, Richard

AU - Barnes, Rosemary

AU - Vazquez, Jose

AU - Larone, Davise

AU - Rinaldi, Mike

AU - Reyes, Heidi

AU - Santiago, Axel

PY - 2008/3/1

Y1 - 2008/3/1

N2 - We examined data from the ARTEMIS DISK Antifungal Surveillance Program to describe geographic and temporal trends in the isolation of Candida parapsilosis from clinical specimens and the in vitro susceptibilities of 9,371 isolates to fluconazole and voriconazole. We also report the in vitro susceptibility of bloodstream infection (BSI) isolates of C. parapsilosis to the echinocandins, anidulafungin, caspofungin, and micafungin. C. parapsilosis represented 6.6% of the 141,383 isolates of Candida collected from 2001 to 2005 and was most common among isolates from North America (14.3%) and Latin America (9.9%). High levels of susceptibility to both fluconazole (90.8 to 95.8%) and voriconazole (95.3 to 98.1%) were observed in all geographic regions with the exception of the Africa and Middle East region (79.3 and 85.8% susceptible to fluconazole and voriconazole, respectively). C. parapsilosis was most often isolated from blood and skin and/or soft tissue specimens and from patients hospitalized in the medical, surgical, intensive care unit (ICU) and dermatology services. Notably, isolates from the surgical ICU were the least susceptible to fluconazole (86.3%). There was no evidence of increasing azole resistance over time among C. parapsilosis isolates tested from 2001 to 2005. Of BSI isolates tested against the three echinocandins, 92, 99, and 100% were inhibited by concentrations of ≤2 μg/ml of anidulafungin (621 isolates tested), caspofungin (1,447 isolates tested), and micafungin (539 isolates tested), respectively. C. parapsilosis is a ubiquitous pathogen that remains susceptible to the azoles and echinocandins; however, both the frequency of isolation and the resistance of C. parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service.

AB - We examined data from the ARTEMIS DISK Antifungal Surveillance Program to describe geographic and temporal trends in the isolation of Candida parapsilosis from clinical specimens and the in vitro susceptibilities of 9,371 isolates to fluconazole and voriconazole. We also report the in vitro susceptibility of bloodstream infection (BSI) isolates of C. parapsilosis to the echinocandins, anidulafungin, caspofungin, and micafungin. C. parapsilosis represented 6.6% of the 141,383 isolates of Candida collected from 2001 to 2005 and was most common among isolates from North America (14.3%) and Latin America (9.9%). High levels of susceptibility to both fluconazole (90.8 to 95.8%) and voriconazole (95.3 to 98.1%) were observed in all geographic regions with the exception of the Africa and Middle East region (79.3 and 85.8% susceptible to fluconazole and voriconazole, respectively). C. parapsilosis was most often isolated from blood and skin and/or soft tissue specimens and from patients hospitalized in the medical, surgical, intensive care unit (ICU) and dermatology services. Notably, isolates from the surgical ICU were the least susceptible to fluconazole (86.3%). There was no evidence of increasing azole resistance over time among C. parapsilosis isolates tested from 2001 to 2005. Of BSI isolates tested against the three echinocandins, 92, 99, and 100% were inhibited by concentrations of ≤2 μg/ml of anidulafungin (621 isolates tested), caspofungin (1,447 isolates tested), and micafungin (539 isolates tested), respectively. C. parapsilosis is a ubiquitous pathogen that remains susceptible to the azoles and echinocandins; however, both the frequency of isolation and the resistance of C. parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service.

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UR - http://www.scopus.com/inward/citedby.url?scp=40749148116&partnerID=8YFLogxK

U2 - 10.1128/JCM.02122-07

DO - 10.1128/JCM.02122-07

M3 - Article

C2 - 18199791

AN - SCOPUS:40749148116

VL - 46

SP - 842

EP - 849

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 3

ER -