Germ Cell Testicular Tumors—Contemporary Diagnosis, Staging and Management of Localized and Advanced disease

Hanan Goldberg, Zachary W A Klaassen, Thenappan Chandrasekar, Neil Fleshner, Robert J. Hamilton, Michael A.S. Jewett

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Germ cell testicular tumors are the most commonly diagnosed cancer in young men, with cure rates exceeding 95%. Clinical stage 1 disease is the most common manifestation, with radical orchiectomy curing the majority of Clinical stage 1 patients, making active surveillance the treatment of choice, with a cancer specific survival nearing 100% and low relapse rates. However, in metastatic disease, chemotherapy, radiotherapy, and surgery are curative options. Chemotherapy remains the mainstay of therapy for advanced disease with surgical management of residual disease. Patients with advanced disease should be treated in high volume experienced academic centers with multidisciplinary teams. Research exploring refinement of diagnosis and treatment, and lowering treatment burden is underway.

Original languageEnglish (US)
Pages (from-to)8-19
Number of pages12
JournalUrology
Volume125
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

Germ Cells
Drug Therapy
Orchiectomy
Therapeutics
Disease Management
Neoplasms
Radiotherapy
Recurrence
Survival
Research

ASJC Scopus subject areas

  • Urology

Cite this

Germ Cell Testicular Tumors—Contemporary Diagnosis, Staging and Management of Localized and Advanced disease. / Goldberg, Hanan; Klaassen, Zachary W A; Chandrasekar, Thenappan; Fleshner, Neil; Hamilton, Robert J.; Jewett, Michael A.S.

In: Urology, Vol. 125, 01.03.2019, p. 8-19.

Research output: Contribution to journalReview article

Goldberg, Hanan ; Klaassen, Zachary W A ; Chandrasekar, Thenappan ; Fleshner, Neil ; Hamilton, Robert J. ; Jewett, Michael A.S. / Germ Cell Testicular Tumors—Contemporary Diagnosis, Staging and Management of Localized and Advanced disease. In: Urology. 2019 ; Vol. 125. pp. 8-19.
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