TY - JOUR
T1 - Getting to the site of inflammation
T2 - The leukocyte adhesion cascade updated
AU - Ley, Klaus
AU - Laudanna, Carlo
AU - Cybulsky, Myron I.
AU - Nourshargh, Sussan
N1 - Funding Information:
K.L. is funded by the National Institutes of Health. S.N. is funded by the Wellcome Trust UK and the British Heart Foundation. We wish to thank M.-B. Voisin for his contribution to FIG. 3. M.C. is a Career Investigator of the Heart and Stroke Foundation of Ontario and is funded by the Canadian Institutes of Health Research.
PY - 2007/9
Y1 - 2007/9
N2 - Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation and firm adhesion have recently been augmented and refined. Slow rolling, adhesion strengthening, intraluminal crawling and paracellular and transcellular migration are now recognized as separate, additional steps. In neutrophils, a second activation pathway has been discovered that does not require signalling through G-protein-coupled receptors and the signalling steps leading to integrin activation are beginning to emerge. This Review focuses on new aspects of one of the central paradigms of inflammation and immunity - the leukocyte adhesion cascade.
AB - Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation and firm adhesion have recently been augmented and refined. Slow rolling, adhesion strengthening, intraluminal crawling and paracellular and transcellular migration are now recognized as separate, additional steps. In neutrophils, a second activation pathway has been discovered that does not require signalling through G-protein-coupled receptors and the signalling steps leading to integrin activation are beginning to emerge. This Review focuses on new aspects of one of the central paradigms of inflammation and immunity - the leukocyte adhesion cascade.
UR - http://www.scopus.com/inward/record.url?scp=34548230927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548230927&partnerID=8YFLogxK
U2 - 10.1038/nri2156
DO - 10.1038/nri2156
M3 - Review article
C2 - 17717539
AN - SCOPUS:34548230927
SN - 1474-1733
VL - 7
SP - 678
EP - 689
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 9
ER -