Ameloblastoma is an odontogenic tumor that usually occurs in the mandible. It is an aggressive but benign tumor of epithelial origin that is rarely metastatic. We report the case of a 53-year-old woman who had a massive ameloblastoma of the mandible. The tumor measured 15.2 x 11.4 x 12.0 cm. The patient had oral bleeding that required a transfusion. The workup included three-dimensional imaging, arteriography, and embolization to control bleeding. Surgical management entailed the resection of the entire left mandible and right symphysis, followed by reconstruction with a free fibular flap. To our knowledge, this is the largest reported ameloblastoma managed with three-dimensional imaging, radical resection, and free-flap reconstruction. This article also reviews aspects of the differential diagnosis, pathology, and management of jaw tumors.
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