Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe 2 O 3 Superparamagnetic Nanoparticles for Completely Killing Tumors

Jung Tak Jang, Jooyoung Lee, Jiyun Seon, Eric Ju, Minkyu Kim, Young Il Kim, Min Gyu Kim, Yasushi Takemura, Ali Syed Arbab, Keon Wook Kang, Ki Ho Park, Sun Ha Paek, Seongtae Bae

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (H appl ·f appl < 3.0–5.0 × 10 9 A m −1 s −1 ), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe 2 O 3 (Mg 0.13 -γFe 2 O 3 ) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m 2 kg −1 , which is an ≈100 times higher than that of commercial Fe 3 O 4 (Feridex, ILP = 0.15 nH m 2 kg −1 ) at H appl ·f appl = 1.23 × 10 9 A m −1 s −1 are reported. The significantly enhanced heat induction characteristics of Mg 0.13 -γFe 2 O 3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg 2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe 2 O 3 instead of well-known Fe 3 O 4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg 0.13 -γFe 2 O 3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg 0.13 -γFe 2 O 3 nanofluids show promising hyperthermia effects to completely kill the tumors.

Original languageEnglish (US)
Article number1704362
JournalAdvanced Materials
Volume30
Issue number6
DOIs
StatePublished - Feb 8 2018

Fingerprint

Magnesium
Tumors
Nanoparticles
Induction heating
Oncology
Magnetic fluids
Magnetic susceptibility
Biocompatibility
Vacancies
Cations
Positive ions
Magnetic fields
Hot Temperature
Biological Availability
Renaissance
ferumoxides

Keywords

  • Mg-doped γ-Fe O nanoparticles
  • cancer treatment
  • giant magnetic heat induction
  • intrinsic loss power
  • magnetic fluid hyperthermia

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe 2 O 3 Superparamagnetic Nanoparticles for Completely Killing Tumors . / Jang, Jung Tak; Lee, Jooyoung; Seon, Jiyun; Ju, Eric; Kim, Minkyu; Kim, Young Il; Kim, Min Gyu; Takemura, Yasushi; Arbab, Ali Syed; Kang, Keon Wook; Park, Ki Ho; Paek, Sun Ha; Bae, Seongtae.

In: Advanced Materials, Vol. 30, No. 6, 1704362, 08.02.2018.

Research output: Contribution to journalArticle

Jang, JT, Lee, J, Seon, J, Ju, E, Kim, M, Kim, YI, Kim, MG, Takemura, Y, Arbab, AS, Kang, KW, Park, KH, Paek, SH & Bae, S 2018, ' Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe 2 O 3 Superparamagnetic Nanoparticles for Completely Killing Tumors ', Advanced Materials, vol. 30, no. 6, 1704362. https://doi.org/10.1002/adma.201704362
Jang, Jung Tak ; Lee, Jooyoung ; Seon, Jiyun ; Ju, Eric ; Kim, Minkyu ; Kim, Young Il ; Kim, Min Gyu ; Takemura, Yasushi ; Arbab, Ali Syed ; Kang, Keon Wook ; Park, Ki Ho ; Paek, Sun Ha ; Bae, Seongtae. / Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe 2 O 3 Superparamagnetic Nanoparticles for Completely Killing Tumors In: Advanced Materials. 2018 ; Vol. 30, No. 6.
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abstract = "Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (H appl ·f appl < 3.0–5.0 × 10 9 A m −1 s −1 ), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe 2 O 3 (Mg 0.13 -γFe 2 O 3 ) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m 2 kg −1 , which is an ≈100 times higher than that of commercial Fe 3 O 4 (Feridex, ILP = 0.15 nH m 2 kg −1 ) at H appl ·f appl = 1.23 × 10 9 A m −1 s −1 are reported. The significantly enhanced heat induction characteristics of Mg 0.13 -γFe 2 O 3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg 2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe 2 O 3 instead of well-known Fe 3 O 4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg 0.13 -γFe 2 O 3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg 0.13 -γFe 2 O 3 nanofluids show promising hyperthermia effects to completely kill the tumors.",
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AU - Kim, Minkyu

AU - Kim, Young Il

AU - Kim, Min Gyu

AU - Takemura, Yasushi

AU - Arbab, Ali Syed

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AU - Park, Ki Ho

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