Abstract
Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (Happl·fappl < 3.0–5.0 × 109 A m−1 s−1), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe2O3 (Mg0.13-γFe2O3) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m2 kg−1, which is an ≈100 times higher than that of commercial Fe3O4 (Feridex, ILP = 0.15 nH m2 kg−1) at Happl·fappl = 1.23 × 109 A m−1 s−1 are reported. The significantly enhanced heat induction characteristics of Mg0.13-γFe2O3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe2O3 instead of well-known Fe3O4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg0.13-γFe2O3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg0.13-γFe2O3 nanofluids show promising hyperthermia effects to completely kill the tumors.
| Original language | English (US) |
|---|---|
| Article number | 1704362 |
| Journal | Advanced Materials |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - Feb 8 2018 |
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Keywords
- Mg-doped γ-FeO nanoparticles
- cancer treatment
- giant magnetic heat induction
- intrinsic loss power
- magnetic fluid hyperthermia
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2O3 Superparamagnetic Nanoparticles for Completely Killing Tumors. / Jang, Jung Tak; Lee, Jooyoung; Seon, Jiyun; Ju, Eric; Kim, Minkyu; Kim, Young Il; Kim, Min Gyu; Takemura, Yasushi; Arbab, Ali Syed; Kang, Keon Wook; Park, Ki Ho; Paek, Sun Ha; Bae, Seongtae.
In: Advanced Materials, Vol. 30, No. 6, 1704362, 08.02.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2O3 Superparamagnetic Nanoparticles for Completely Killing Tumors
AU - Jang, Jung Tak
AU - Lee, Jooyoung
AU - Seon, Jiyun
AU - Ju, Eric
AU - Kim, Minkyu
AU - Kim, Young Il
AU - Kim, Min Gyu
AU - Takemura, Yasushi
AU - Arbab, Ali Syed
AU - Kang, Keon Wook
AU - Park, Ki Ho
AU - Paek, Sun Ha
AU - Bae, Seongtae
PY - 2018/2/8
Y1 - 2018/2/8
N2 - Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (Happl·fappl < 3.0–5.0 × 109 A m−1 s−1), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe2O3 (Mg0.13-γFe2O3) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m2 kg−1, which is an ≈100 times higher than that of commercial Fe3O4 (Feridex, ILP = 0.15 nH m2 kg−1) at Happl·fappl = 1.23 × 109 A m−1 s−1 are reported. The significantly enhanced heat induction characteristics of Mg0.13-γFe2O3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe2O3 instead of well-known Fe3O4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg0.13-γFe2O3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg0.13-γFe2O3 nanofluids show promising hyperthermia effects to completely kill the tumors.
AB - Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (Happl·fappl < 3.0–5.0 × 109 A m−1 s−1), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe2O3 (Mg0.13-γFe2O3) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m2 kg−1, which is an ≈100 times higher than that of commercial Fe3O4 (Feridex, ILP = 0.15 nH m2 kg−1) at Happl·fappl = 1.23 × 109 A m−1 s−1 are reported. The significantly enhanced heat induction characteristics of Mg0.13-γFe2O3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe2O3 instead of well-known Fe3O4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg0.13-γFe2O3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg0.13-γFe2O3 nanofluids show promising hyperthermia effects to completely kill the tumors.
KW - Mg-doped γ-FeO nanoparticles
KW - cancer treatment
KW - giant magnetic heat induction
KW - intrinsic loss power
KW - magnetic fluid hyperthermia
UR - http://www.scopus.com/inward/record.url?scp=85038393988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038393988&partnerID=8YFLogxK
U2 - 10.1002/adma.201704362
DO - 10.1002/adma.201704362
M3 - Article
C2 - 29266514
AN - SCOPUS:85038393988
VL - 30
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 6
M1 - 1704362
ER -