Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis

a meta-analysis

Amanda F. Stadler, Patrícia D.M. Angst, Roger Mauricio Arce Munoz, Sabrina C. Gomes, Rui V. Oppermann, Cristiano Susin

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Aims: To compare gingival crevicular fluid (GCF) cytokines/chemokines levels between periodontally healthy subjects and subjects diagnosed with chronic periodontitis (ChP), before and after non-surgical periodontal treatment, and to establish their predictive value for periodontal disease progression. Methods: Studies indexed in MEDLINE and EMBASE published in English, Portuguese and Spanish were eligible for this review. Database searches up to December 2015, and manual search of the reference list from reviews and selected articles was performed. Only studies providing data on GCF cytokines/chemokines levels in subjects diagnosed with ChP and periodontally healthy controls were included. Cross-sectional, case series, single-arm clinical studies, randomized controlled trials and prospective/retrospective cohort studies were included. Meta-analyses were conducted for those cytokines/chemokines with at least three available studies. Results: GCF levels of IL-1β, IL-6, IFN-γ and MCP-1/CCL2 were significantly higher in subjects diagnosed with ChP than periodontally healthy subjects. A significant decrease in GCF levels of IL-1β and IL-17 was observed after non-surgical periodontal treatment, whereas a significant increase was observed for IL-4. Conclusion: Evidence for significant differences between periodontal health and ChP was observed for a few cytokines and one chemokine. No conclusions could be drawn with regards to increased risk of disease progression.

Original languageEnglish (US)
Pages (from-to)727-745
Number of pages19
JournalJournal of Clinical Periodontology
Volume43
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Gingival Crevicular Fluid
Chronic Periodontitis
Chemokines
Meta-Analysis
Cytokines
Interleukin-1
Disease Progression
Healthy Volunteers
Interleukin-17
Periodontal Diseases
MEDLINE
Interleukin-4
Interleukin-6
Cohort Studies
Randomized Controlled Trials
Retrospective Studies
Databases
Health
Therapeutics

Keywords

  • chemokines
  • cytokines
  • gingival crevicular fluid
  • inflammation
  • periodontal diseases
  • periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis : a meta-analysis. / Stadler, Amanda F.; Angst, Patrícia D.M.; Arce Munoz, Roger Mauricio; Gomes, Sabrina C.; Oppermann, Rui V.; Susin, Cristiano.

In: Journal of Clinical Periodontology, Vol. 43, No. 9, 01.09.2016, p. 727-745.

Research output: Contribution to journalReview article

Stadler, Amanda F. ; Angst, Patrícia D.M. ; Arce Munoz, Roger Mauricio ; Gomes, Sabrina C. ; Oppermann, Rui V. ; Susin, Cristiano. / Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis : a meta-analysis. In: Journal of Clinical Periodontology. 2016 ; Vol. 43, No. 9. pp. 727-745.
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