Gingival overgrowth and dental alveolar alterations: Possible mechanisms of cyclosporin-induced tooth migration. An experimental study in the rat

Earl Fu, Shin Nieh, Ulf M E Wikesjö, Lin Fu-Gong, E. Chin Shen

Research output: Contribution to journalArticle

14 Scopus citations


THE INTER-INCISAL DISTANCE and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-incisal distance and gingival dimensions, including bucco-lingual width and vertical height, were assessed biweekly from alginate impressed stone models. Animals were sacrificed at the end of the study and tissue sections were obtained from the anterior region of the mandible for histopathological evaluation. Both the inter-incisal distance and the dimension of the interdental papilla were significantly greater in CSA- exposed animals compared to control. The significant alteration appeared earlier in the papillary dimensions than that in the interdental distance. Particular histopathological alterations of the soft and hard tissues of the periodontium were observed in CSA-exposed animals. Within limitations of the study, we suggest that the CSA-induced gingival overgrowth may offer an active force contributing to observed tooth movement, however, remarkable alveolar remodeling should be considered as an undetermined factor for the movement.

Original languageEnglish (US)
Pages (from-to)1231-1236
Number of pages6
JournalJournal of periodontology
Issue number12
Publication statusPublished - Dec 1997



  • Animal studies
  • Gingiva/anatomy and histology, cyclosporin A/adverse effects
  • Tooth migration

ASJC Scopus subject areas

  • Periodontics

Cite this