Glial Regulation of Neuronal Function: From Synapse to Systems Physiology

J. G. Tasker, S. H.R. Oliet, J. S. Bains, C. H. Brown, J. E. Stern

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Classically, glia have been regarded as non-excitable cells that provide nourishment and physical scaffolding for neurones. However, it is now generally accepted that glia are active participants in brain function that can modulate neuronal communication via several mechanisms. Investigations of anatomical plasticity in the magnocellular neuroendocrine system of the hypothalamic paraventricular and supraoptic nuclei led the way in the development of much of our understanding of glial regulation of neuronal activity. In this review, we provide an overview of glial regulation of magnocellular neurone activity from a historical perspective of the development of our knowledge of the morphological changes that are evident in the paraventricular and supraoptic nuclei. We also focus on recent data from the authors' laboratories presented at the 9th World Congress on Neurohypophysial Hormones that have contributed to our understanding of the multiple mechanisms by which glia modulate the activity of neurones, including: gliotransmitter modulation of synaptic transmission; trans-synaptic modulation by glial neurotransmitter transporter regulation of neurotransmitter spillover; and glial neurotransmitter transporter modulation of excitability by regulation of ambient neurotransmitter levels and their action on extrasynaptic receptors. The magnocellular neuroendocrine system secretes oxytocin and vasopressin from the posterior pituitary gland to control birth, lactation and body fluid balance, and we finally speculate as to whether glial regulation of individual magnocellular neurones might co-ordinate population activity to respond appropriately to altered physiological circumstances.

Original languageEnglish (US)
Pages (from-to)566-576
Number of pages11
JournalJournal of Neuroendocrinology
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2012

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Neuroglia
Synapses
Neurotransmitter Transport Proteins
Neurons
Supraoptic Nucleus
Neurosecretory Systems
Paraventricular Hypothalamic Nucleus
Neurotransmitter Agents
Posterior Pituitary Hormones
Posterior Pituitary Gland
Water-Electrolyte Balance
Body Fluids
Oxytocin
Vasopressins
Contraception
Lactation
Synaptic Transmission
Brain
Population

Keywords

  • Dehydration
  • Lactation
  • Oxytocin
  • Paraventricular nucleus
  • Supraoptic nucleus
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Tasker, J. G., Oliet, S. H. R., Bains, J. S., Brown, C. H., & Stern, J. E. (2012). Glial Regulation of Neuronal Function: From Synapse to Systems Physiology. Journal of Neuroendocrinology, 24(4), 566-576. https://doi.org/10.1111/j.1365-2826.2011.02259.x

Glial Regulation of Neuronal Function : From Synapse to Systems Physiology. / Tasker, J. G.; Oliet, S. H.R.; Bains, J. S.; Brown, C. H.; Stern, J. E.

In: Journal of Neuroendocrinology, Vol. 24, No. 4, 01.04.2012, p. 566-576.

Research output: Contribution to journalReview article

Tasker, J. G. ; Oliet, S. H.R. ; Bains, J. S. ; Brown, C. H. ; Stern, J. E. / Glial Regulation of Neuronal Function : From Synapse to Systems Physiology. In: Journal of Neuroendocrinology. 2012 ; Vol. 24, No. 4. pp. 566-576.
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