Global stability for a 2n+1 dimensional HIV/AIDS epidemic model with treatments

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11 Scopus citations

Abstract

In this work, we derive and analyze a 2n+1-dimensional deterministic differential equation modeling the transmission and treatment of HIV (Human Immunodeficiency Virus) disease. The model is extended to a stochastic differential equation by introducing noise in the transmission rate of the disease. A theoretical treatment strategy of regular HIV testing and immediate treatment with Antiretroviral Therapy (ART) is investigated in the presence and absence of noise. By defining R 0, n , R t, n and R t,n as the deterministic basic reproduction number in the absence of ART treatments, deterministic basic reproduction number in the presence of ART treatments and stochastic reproduction number in the presence of ART treatment, respectively, we discuss the stability of the infection-free and endemic equilibrium in the presence and absence of treatments by first deriving the closed form expression for R 0, n , R t, n and R t,n . We show that there is enough treatment to avoid persistence of infection in the endemic equilibrium state if R t,n =1. We further show by studying the effect of noise in the transmission rate of the disease that transient epidemic invasion can still occur even if R t, n < 1. This happens due to the presence of noise (with high intensity) in the transmission rate, causing R t,n >1. A threshold criterion for epidemic invasion in the presence and absence of noise is derived. Numerical simulation is presented for validation.

Original languageEnglish (US)
Pages (from-to)138-152
Number of pages15
JournalMathematical Biosciences
Volume299
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • HIV
  • Infection
  • Reproduction number
  • Stability
  • Stochastic model
  • Susceptible
  • Treatment

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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