TY - JOUR
T1 - Glomerular filtration rate and urinary albumin excretion rate in systemic lupus erythematosus
AU - Cottiero, R. A.
AU - Madaio, M. P.
AU - Levey, A. S.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Our objective was to more precisely determine glomerular function in patients with systemic lupus erythematosus (SLE), without abnormalities in renal function, as determined by standard clinical laboratory tests. Our long-term goal is to identify patients during clinical quiescence who may be at high risk of developing progression to renal failure from lupus nephritis. We studied three groups of subjects: 8 patients with SLE and a history of nephritis, now in remission; 25 patients with SLE, without clinical evidence of nephritis, now or in the past; and 5 healthy women (normal controls). At the time of study, urinalysis, serum creatinine and 24-hour urine total protein excretion were within the normal range in each subject. We measured glomerular filtration rate (GFR) by 125I-iothalamate clearance. and albumin excretion rate (AER) by enzyme-linked immunosorbent assay (ELISA) in timed urine specimens. In addition, we compared 4-hour AER with 24-hour AER and spot urine albumin/creatinine ratio (A/C). Among patients with a history of nephritis now in remission, mean GFR was slightly but not significantly lower and mean GFR was elevated (p < 0.03). Among patients with SLE without a history of nephritis, mean GFR was normal, but the variance in GFR was greater than normal (p < 0.005). Seven patients without nephritis (28%) had either hyperfiltration or hypofiltration. Mean AER was normal, but 3 other patients (12%) had elevated AER. There was no correlation of GFR and AER among patients in either group. Correlations (r) of spot urine A/C and 24-hour AER with 4-hour AER were 0.93 (p < 0.001) and 0.88 (p < 0.001), respectively. We conclude that most patients with SLE and a history of nephritis now in remission have persistent abnormalities in glomerular function, and as many as 40% of patients without a history of nephritis also have subtle defects in glomerular function. Whether these abnormalities in glomerular function define a subset of patients at higher risk of developing renal failure, independent of disease activity, requires further study. Spot urine A/C is a valid measure of AER in SLE.
AB - Our objective was to more precisely determine glomerular function in patients with systemic lupus erythematosus (SLE), without abnormalities in renal function, as determined by standard clinical laboratory tests. Our long-term goal is to identify patients during clinical quiescence who may be at high risk of developing progression to renal failure from lupus nephritis. We studied three groups of subjects: 8 patients with SLE and a history of nephritis, now in remission; 25 patients with SLE, without clinical evidence of nephritis, now or in the past; and 5 healthy women (normal controls). At the time of study, urinalysis, serum creatinine and 24-hour urine total protein excretion were within the normal range in each subject. We measured glomerular filtration rate (GFR) by 125I-iothalamate clearance. and albumin excretion rate (AER) by enzyme-linked immunosorbent assay (ELISA) in timed urine specimens. In addition, we compared 4-hour AER with 24-hour AER and spot urine albumin/creatinine ratio (A/C). Among patients with a history of nephritis now in remission, mean GFR was slightly but not significantly lower and mean GFR was elevated (p < 0.03). Among patients with SLE without a history of nephritis, mean GFR was normal, but the variance in GFR was greater than normal (p < 0.005). Seven patients without nephritis (28%) had either hyperfiltration or hypofiltration. Mean AER was normal, but 3 other patients (12%) had elevated AER. There was no correlation of GFR and AER among patients in either group. Correlations (r) of spot urine A/C and 24-hour AER with 4-hour AER were 0.93 (p < 0.001) and 0.88 (p < 0.001), respectively. We conclude that most patients with SLE and a history of nephritis now in remission have persistent abnormalities in glomerular function, and as many as 40% of patients without a history of nephritis also have subtle defects in glomerular function. Whether these abnormalities in glomerular function define a subset of patients at higher risk of developing renal failure, independent of disease activity, requires further study. Spot urine A/C is a valid measure of AER in SLE.
KW - Albumin excretion rate
KW - Glomerular filtration rate
KW - Renal function
KW - Systemic lupus erythematosus
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U2 - 10.1159/000188429
DO - 10.1159/000188429
M3 - Article
C2 - 7723895
AN - SCOPUS:0028801593
VL - 69
SP - 140
EP - 146
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 2
ER -