Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects

R. J. Bollag, Q. Zhong, K. H. Ding, P. Phillips, L. Zhong, F. Qin, J. Cranford, A. L. Mulloy, R. Cameron, C. M. Isales

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an 'entero-osseous axis'. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume177
Issue number1-2
DOIs
StatePublished - May 25 2001

Fingerprint

Gastric Inhibitory Polypeptide
Hormones
Bone
Nutrients
Bone and Bones
Food
Anabolic Agents
Peptide Receptors
Ovariectomy
Adrenal Glands
Adipocytes
Endothelium
Brain
Fats
Availability
Insulin
Tissue
Glucose

Keywords

  • Bone
  • Bone mineral density
  • GIP receptor
  • Osteoporosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. / Bollag, R. J.; Zhong, Q.; Ding, K. H.; Phillips, P.; Zhong, L.; Qin, F.; Cranford, J.; Mulloy, A. L.; Cameron, R.; Isales, C. M.

In: Molecular and Cellular Endocrinology, Vol. 177, No. 1-2, 25.05.2001, p. 35-41.

Research output: Contribution to journalArticle

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AU - Qin, F.

AU - Cranford, J.

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