Abstract
Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an 'entero-osseous axis'. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution.
Original language | English (US) |
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Pages (from-to) | 35-41 |
Number of pages | 7 |
Journal | Molecular and Cellular Endocrinology |
Volume | 177 |
Issue number | 1-2 |
DOIs | |
State | Published - May 25 2001 |
Keywords
- Bone
- Bone mineral density
- GIP receptor
- Osteoporosis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology