Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

Q. Zhong, R. J. Bollag, D. T. Dransfield, J. Gasalla-Herraiz, K. H. Ding, L. Min, C. M. Isales

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Glucose-dependent insulinotropic peptide (GIP) potentiates glucose-induced insulin secretion. In addition, GIP has vasoconstrictive or vasodilatory properties depending on the vascular bed affected. In order to assess whether this effect could be related to differences in GIP receptor expression, several different endothelial cell types were examined for GIP receptor expression. GIP receptor splice variants were detected and varied depending on the endothelial cell type. Furthermore, stimulation of these cells with GIP led to cell type dependent differences in activation of the calcium and cAMP signaling pathways. To our knowledge this is the first physiological characterization of receptors for GIP in endothelial cells. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)1427-1432
Number of pages6
JournalPeptides
Volume21
Issue number9
DOIs
StatePublished - Nov 8 2000

Keywords

  • Endothelium
  • Glucose-dependent insulinotropic polypeptide
  • Peptide hormone receptors
  • Splice variants

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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