TY - JOUR
T1 - Glucose Metabolism in Acute Kidney Injury and Kidney Repair
AU - Wen, Lu
AU - Li, Ying
AU - Li, Siyao
AU - Hu, Xiaoru
AU - Wei, Qingqing
AU - Dong, Zheng
N1 - Funding Information:
The authors were supported by grants from the National Institutes of Health of USA (DK058831 and DK087843) and Department of Veterans Administration of USA (BX000319).
Publisher Copyright:
Copyright © 2021 Wen, Li, Li, Hu, Wei and Dong.
PY - 2021/11/29
Y1 - 2021/11/29
N2 - The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases.
AB - The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases.
KW - SGLTs
KW - glucose metabolism
KW - glycolysis (warburg effect)
KW - kidney injury and repair
KW - renal fibrosis
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U2 - 10.3389/fmed.2021.744122
DO - 10.3389/fmed.2021.744122
M3 - Review article
AN - SCOPUS:85121448697
SN - 2296-858X
VL - 8
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 744122
ER -