Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans

Donovan Thomas, Katherine Klein, Elias Manavathu, Jonathan R. Dimmock, Bulent Mutus

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Glutathione (GSH) levels were directly monitored by reverse phase HPLC during the thermal yeast-to-mycelial induction of Candida albicans. The GSH levels decreased ∼ 100-fold within 120 min which corresponded to the time of maximal yeast-to-mold conversion. The yeast to mold conversion was inhibited by 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one (CDDP) [1], a thiol-specific alkylator, which prevented the decline in GSH levels. These results are discussed with respect to the potential involvement of intracellular GSH levels in regulation of the yeast-to-mold dimorphism in Candida albicans.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalFEMS Microbiology Letters
Issue number2-3
StatePublished - Jan 15 1991



  • Candida albicans
  • Glutathione
  • Yeast to mold transition

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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