Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans

Donovan Thomas, Katherine Klein, Elias Kurian Manavathu, Jonathan R. Dimmock, Bulent Mutus

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Glutathione (GSH) levels were directly monitored by reverse phase HPLC during the thermal yeast-to-mycelial induction of Candida albicans. The GSH levels decreased ∼ 100-fold within 120 min which corresponded to the time of maximal yeast-to-mold conversion. The yeast to mold conversion was inhibited by 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one (CDDP) [1], a thiol-specific alkylator, which prevented the decline in GSH levels. These results are discussed with respect to the potential involvement of intracellular GSH levels in regulation of the yeast-to-mold dimorphism in Candida albicans.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalFEMS Microbiology Letters
Volume77
Issue number2-3
DOIs
StatePublished - Jan 15 1991

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Candida albicans
Glutathione
Hot Temperature
Yeasts
Fungi
Alkylating Agents
Sulfhydryl Compounds
High Pressure Liquid Chromatography

Keywords

  • Candida albicans
  • Glutathione
  • Yeast to mold transition

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans. / Thomas, Donovan; Klein, Katherine; Manavathu, Elias Kurian; Dimmock, Jonathan R.; Mutus, Bulent.

In: FEMS Microbiology Letters, Vol. 77, No. 2-3, 15.01.1991, p. 331-334.

Research output: Contribution to journalArticle

Thomas, Donovan ; Klein, Katherine ; Manavathu, Elias Kurian ; Dimmock, Jonathan R. ; Mutus, Bulent. / Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans. In: FEMS Microbiology Letters. 1991 ; Vol. 77, No. 2-3. pp. 331-334.
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