Glycolipid and glycoprotein expression during neural development

Research output: Contribution to journalArticle

Abstract

In mammals, the central and peripheral nervous systems are developmentally derived from cells in the neural plate. Specific ectodermal cells in this area form the neural tube and neural crest during the early developmental stage. The neural tube is the origin of the central nervous system which consists of both the brain and spinal cord, whereas neural crest cells are precursors of the peripheral nervous system. During neural tube formation and neural crest development, carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, are expressed primarily on the outer surface of cell plasma membranes. The structural diversity of their carbohydrate moieties coupled with their expression at different stages of development makes these molecules excellent biomarkers for various cell types. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycoconjugates during neural development.

Original languageEnglish (US)
Pages (from-to)185-222
Number of pages38
JournalAdvances in neurobiology
Volume9
DOIs
StatePublished - 2014

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Neural Tube
Neural Crest
Glycolipids
Neurology
Glycoproteins
Peripheral Nervous System
Cell membranes
Molecules
Central Nervous System
Carbohydrates
Cell Membrane
Neural Plate
Signal transduction
Glycoconjugates
Mammals
Cell proliferation
Biomarkers
Proteoglycans
Cell Differentiation
Signal Transduction

Keywords

  • Journal Article

Cite this

Glycolipid and glycoprotein expression during neural development. / Yu, Robert K; Itokazu, Yutaka.

In: Advances in neurobiology, Vol. 9, 2014, p. 185-222.

Research output: Contribution to journalArticle

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