Glycolipid Antigens in Neural Stem Cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The central nervous system, consisting of the brain and the spinal cord, is generated from progenitor cells that are generally recognized as neural stem cells (NSCs). NSCs are undifferentiated neural cells characterized by their high proliferative potential and capacity for self-renewal with retention of multipotency to differentiate into neurons and glia. Throughout neural development and cell differentiation, dynamic changes are observed in the composition of carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, that are expressed primarily on the outer surface of plasma membranes. The structural diversity of their carbohydrate moieties coupled with their unique spatial and temporal expression make these molecules excellent biomarkers for various cell types at different stages of development. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycolipids in NSCs and differentiation.

Original languageEnglish (US)
Title of host publicationNeural Surface Antigens
Subtitle of host publicationFrom Basic Biology Towards Biomedical Applications
PublisherElsevier Inc.
Pages91-102
Number of pages12
ISBN (Electronic)9780128011263
ISBN (Print)9780128007815
DOIs
StatePublished - Apr 15 2015

Fingerprint

Neural Stem Cells
glycolipids
Glycolipids
Stem cells
stem cells
Cell Differentiation
antigens
Antigens
Molecules
neurons
Carbohydrates
Signal transduction
Cell proliferation
Neurology
Biomarkers
Proteoglycans
Cell membranes
Neuroglia
carbohydrate composition
Neurons

Keywords

  • Cell surface microdomain
  • Epigenetics
  • Ganglioside
  • Gliogenesis
  • Glycoconjugate
  • Glycolipid
  • Glycosphingolipid
  • Neural stem cell
  • Neurogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Itokazu, Y., & Yu, R. K. (2015). Glycolipid Antigens in Neural Stem Cells. In Neural Surface Antigens: From Basic Biology Towards Biomedical Applications (pp. 91-102). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800781-5.00008-6

Glycolipid Antigens in Neural Stem Cells. / Itokazu, Yutaka; Yu, Robert K.

Neural Surface Antigens: From Basic Biology Towards Biomedical Applications. Elsevier Inc., 2015. p. 91-102.

Research output: Chapter in Book/Report/Conference proceedingChapter

Itokazu, Y & Yu, RK 2015, Glycolipid Antigens in Neural Stem Cells. in Neural Surface Antigens: From Basic Biology Towards Biomedical Applications. Elsevier Inc., pp. 91-102. https://doi.org/10.1016/B978-0-12-800781-5.00008-6
Itokazu Y, Yu RK. Glycolipid Antigens in Neural Stem Cells. In Neural Surface Antigens: From Basic Biology Towards Biomedical Applications. Elsevier Inc. 2015. p. 91-102 https://doi.org/10.1016/B978-0-12-800781-5.00008-6
Itokazu, Yutaka ; Yu, Robert K. / Glycolipid Antigens in Neural Stem Cells. Neural Surface Antigens: From Basic Biology Towards Biomedical Applications. Elsevier Inc., 2015. pp. 91-102
@inbook{925f0f77295442cc9f8e6ad53f3264f8,
title = "Glycolipid Antigens in Neural Stem Cells",
abstract = "The central nervous system, consisting of the brain and the spinal cord, is generated from progenitor cells that are generally recognized as neural stem cells (NSCs). NSCs are undifferentiated neural cells characterized by their high proliferative potential and capacity for self-renewal with retention of multipotency to differentiate into neurons and glia. Throughout neural development and cell differentiation, dynamic changes are observed in the composition of carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, that are expressed primarily on the outer surface of plasma membranes. The structural diversity of their carbohydrate moieties coupled with their unique spatial and temporal expression make these molecules excellent biomarkers for various cell types at different stages of development. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycolipids in NSCs and differentiation.",
keywords = "Cell surface microdomain, Epigenetics, Ganglioside, Gliogenesis, Glycoconjugate, Glycolipid, Glycosphingolipid, Neural stem cell, Neurogenesis",
author = "Yutaka Itokazu and Yu, {Robert K}",
year = "2015",
month = "4",
day = "15",
doi = "10.1016/B978-0-12-800781-5.00008-6",
language = "English (US)",
isbn = "9780128007815",
pages = "91--102",
booktitle = "Neural Surface Antigens",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Glycolipid Antigens in Neural Stem Cells

AU - Itokazu, Yutaka

AU - Yu, Robert K

PY - 2015/4/15

Y1 - 2015/4/15

N2 - The central nervous system, consisting of the brain and the spinal cord, is generated from progenitor cells that are generally recognized as neural stem cells (NSCs). NSCs are undifferentiated neural cells characterized by their high proliferative potential and capacity for self-renewal with retention of multipotency to differentiate into neurons and glia. Throughout neural development and cell differentiation, dynamic changes are observed in the composition of carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, that are expressed primarily on the outer surface of plasma membranes. The structural diversity of their carbohydrate moieties coupled with their unique spatial and temporal expression make these molecules excellent biomarkers for various cell types at different stages of development. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycolipids in NSCs and differentiation.

AB - The central nervous system, consisting of the brain and the spinal cord, is generated from progenitor cells that are generally recognized as neural stem cells (NSCs). NSCs are undifferentiated neural cells characterized by their high proliferative potential and capacity for self-renewal with retention of multipotency to differentiate into neurons and glia. Throughout neural development and cell differentiation, dynamic changes are observed in the composition of carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, that are expressed primarily on the outer surface of plasma membranes. The structural diversity of their carbohydrate moieties coupled with their unique spatial and temporal expression make these molecules excellent biomarkers for various cell types at different stages of development. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycolipids in NSCs and differentiation.

KW - Cell surface microdomain

KW - Epigenetics

KW - Ganglioside

KW - Gliogenesis

KW - Glycoconjugate

KW - Glycolipid

KW - Glycosphingolipid

KW - Neural stem cell

KW - Neurogenesis

UR - http://www.scopus.com/inward/record.url?scp=84940092716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940092716&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-800781-5.00008-6

DO - 10.1016/B978-0-12-800781-5.00008-6

M3 - Chapter

AN - SCOPUS:84940092716

SN - 9780128007815

SP - 91

EP - 102

BT - Neural Surface Antigens

PB - Elsevier Inc.

ER -