Glycosignaling in neural stem cells: involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.

Robert K Yu, Makoto Yanagisawa

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalJournal of Neurochemistry
Volume103 Suppl 1
DOIs
StatePublished - Jan 1 2007

Fingerprint

Signal transduction
Glycoconjugates
Neural Stem Cells
Stem cells
Signal Transduction
Glycocalyx
Glycolipids
Proteoglycans
Cell membranes
Neuroglia
Neurons
Glycoproteins
Cell Membrane

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Glycosignaling in neural stem cells : involvement of glycoconjugates in signal transduction modulating the neural stem cell fate. / Yu, Robert K; Yanagisawa, Makoto.

In: Journal of Neurochemistry, Vol. 103 Suppl 1, 01.01.2007, p. 39-46.

Research output: Contribution to journalReview article

@article{9c8d1d2e572342058179863a7c01137f,
title = "Glycosignaling in neural stem cells: involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.",
abstract = "The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.",
author = "Yu, {Robert K} and Makoto Yanagisawa",
year = "2007",
month = "1",
day = "1",
doi = "10.1111/j.1471-4159.2007.04710.x",
language = "English (US)",
volume = "103 Suppl 1",
pages = "39--46",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Glycosignaling in neural stem cells

T2 - involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.

AU - Yu, Robert K

AU - Yanagisawa, Makoto

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.

AB - The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=36448943234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36448943234&partnerID=8YFLogxK

U2 - 10.1111/j.1471-4159.2007.04710.x

DO - 10.1111/j.1471-4159.2007.04710.x

M3 - Review article

C2 - 17986138

AN - SCOPUS:36448943234

VL - 103 Suppl 1

SP - 39

EP - 46

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

ER -