Glycosphingolipids in the cerebrospinal fluid of patients with multiple sclerosis

Nobuyuki Miyatani, Megumi Saito, Toshio Ariga, Hiide Yoshino, Robert K Yu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Glycosphingolipids in cerebrospinal fluid (CSF) of individual patients with multiple sclerosis (MS) were analyzed using a glycolipid-overlay technique. The ganglioside composition of CSF of non-MS patients was characterized by an abundance of polysialo species, including GT1b and GQ1b. This pattern is completely different from that of human white or gray matter, in which mono- and disialogangliosides predominate. Increased levels of GM1, either associated with or without increases of other gangliosides, such as GD1a, were observed in 16% of the patients with MS (6 of 37 cases: 1 of 15 progressive progressive stage, 4 of 16 progressive stationary stage, and 1 of 6 relapsing stage). The concentration of GD3 was increased in 23% (3 of 13 cases), whereas 1 of 13 cases (8%) showed a dramatic increase of sulfoglucuronyl paragloboside (SGPG) associated with a high level of GD3. These changes may reflect the cellular changes associated with the known pathological lesions in MS, which are characterized by demyelination, gliosis, and/or remyelination with oligodendrocytic proliferation.

Original languageEnglish (US)
Pages (from-to)205-216
Number of pages12
JournalMolecular and Chemical Neuropathology
Volume13
Issue number3
DOIs
StatePublished - Dec 1 1990

Fingerprint

Glycosphingolipids
Multiple Sclerosis
Cerebrospinal Fluid
Gangliosides
Gliosis
Glycolipids
Demyelinating Diseases
Sclerosis
sialogangliosides

Keywords

  • GD3
  • Ganglioside
  • cerebrospinal fluid
  • demyelination
  • gliosis
  • multiple sclerosis
  • sulfoglucuronyl glycolipids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

Cite this

Glycosphingolipids in the cerebrospinal fluid of patients with multiple sclerosis. / Miyatani, Nobuyuki; Saito, Megumi; Ariga, Toshio; Yoshino, Hiide; Yu, Robert K.

In: Molecular and Chemical Neuropathology, Vol. 13, No. 3, 01.12.1990, p. 205-216.

Research output: Contribution to journalArticle

Miyatani, Nobuyuki ; Saito, Megumi ; Ariga, Toshio ; Yoshino, Hiide ; Yu, Robert K. / Glycosphingolipids in the cerebrospinal fluid of patients with multiple sclerosis. In: Molecular and Chemical Neuropathology. 1990 ; Vol. 13, No. 3. pp. 205-216.
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