GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia

A. Ortiz, J. S. MacDonall, Chandramohan G. Wakade, S. E. Karpiak

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume37
Issue number4
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

G(M1) Ganglioside
Rats
Ischemia
Surgery
Learning
Common Carotid Artery
Middle Cerebral Artery
Ambulatory Surgical Procedures
Reward
Carotid Arteries
Constriction
Food
Control Groups
Cognitive Dysfunction

Keywords

  • Cortical stroke
  • GM1
  • Ganglioside
  • Ischemia
  • Learning
  • Memory
  • Parietal
  • Perseveration
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia. / Ortiz, A.; MacDonall, J. S.; Wakade, Chandramohan G.; Karpiak, S. E.

In: Pharmacology, Biochemistry and Behavior, Vol. 37, No. 4, 01.01.1990, p. 679-684.

Research output: Contribution to journalArticle

@article{89c1394536724032ab487cf8d07ddb86,
title = "GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia",
abstract = "The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.",
keywords = "Cortical stroke, GM1, Ganglioside, Ischemia, Learning, Memory, Parietal, Perseveration, Stroke",
author = "A. Ortiz and MacDonall, {J. S.} and Wakade, {Chandramohan G.} and Karpiak, {S. E.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0091-3057(90)90546-T",
language = "English (US)",
volume = "37",
pages = "679--684",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia

AU - Ortiz, A.

AU - MacDonall, J. S.

AU - Wakade, Chandramohan G.

AU - Karpiak, S. E.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.

AB - The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.

KW - Cortical stroke

KW - GM1

KW - Ganglioside

KW - Ischemia

KW - Learning

KW - Memory

KW - Parietal

KW - Perseveration

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0025633977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025633977&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(90)90546-T

DO - 10.1016/0091-3057(90)90546-T

M3 - Article

C2 - 2093171

AN - SCOPUS:0025633977

VL - 37

SP - 679

EP - 684

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -