GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia

A. Ortiz, J. S. MacDonall, C. G. Wakade, S. E. Karpiak

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume37
Issue number4
DOIs
StatePublished - Dec 1990
Externally publishedYes

Keywords

  • Cortical stroke
  • GM1
  • Ganglioside
  • Ischemia
  • Learning
  • Memory
  • Parietal
  • Perseveration
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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