Gonadotropin modulation of interleukin-1 secretion.

E. J. Corwin, Joseph Gerard Cannon

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

OBJECTIVE: To determine the influence of pituitary gonadotropins, which increase dramatically in concentration at ovulation and in the early years of the postmenopausal transition, on inflammatory cytokine production. DESIGN: Cross-sectional population sampling, in vitro experimentation. PARTICIPANTS: Healthy subjects, including six men, five women between the ages of 18 and 35 years, and four women who were four to 20 years past menopause. METHOD: Isolated peripheral blood mononuclear cells were incubated with physiological concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The concentrations of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) secreted into the supernatants were measured by enzyme-linked immunosorbent assays. RESULTS: Under basal conditions, FSH stimulated IL-1 beta secretion by cells isolated from women in the follicular phase. Under conditions of cellular activation with bacterial lipopolysaccharide, FSH and LH interacted to inhibit IL-1 beta secretion by cells isolated from all groups. The gonadotropins had no significant influence on IL-6 secretion regardless of donor group or cellular activation state. CONCLUSION: The results of this study support the concept that gonadotropins may contribute to the changes in IL-1 beta secretion that occur at the periovulatory and postmenopausal periods.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalThe journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
Volume2
Issue number6
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Physiology

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