Greater fructose consumption is associated with cardiometabolic riskmarkers and visceral adiposity in adolescents

Norman K. Pollock, Vanessa Bundy, William Kanto, Catherine Lucy Davis, Paul J. Bernard, Haidong Zhu, Bernard Gutin, Yanbin Dong

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Though adolescents consume more fructose than any other age group, the relationship between fructose consumption and markers of cardiometabolic risk has not been established in this population. We determined associations of total fructose intake (free fructose plus one-half the intake of free sucrose) with cardiometabolic risk factors and type of adiposity in 559 adolescents aged 14-18 y. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, and C-reactive protein. Diet was assessed with 4-7 24-h recalls and physical activity (PA) was determined by accelerometry. Fat-free soft tissue (FFST) mass and fat mass were measured by DXA. The s.c. abdominal adipose tissue (SAAT) and visceral adipose tissue (VAT) were assessed using MRI. Multiple linear regression, adjusting for age, sex, race, Tanner stage, FFST mass, fat mass, PA, energy intake, fiber intake, and socioeconomic status, revealed that fructose intake was associated with VAT (β = 0.13; P = 0.03) but not SAAT (P = 0.15). Significant linear upward trends across tertiles of fructose intake were observed for systolic blood pressure, fasting glucose, HOMA-IR, and C-reactive protein after adjusting for the same covariates (all P-trend < 0.04). Conversely, significant linear downward trends across tertiles of fructose intake were observed for plasma HDL-cholesterol and adiponectin (both P-trend < 0.03). When SAAT was added as a covariate, these trends persisted (all P-trend < 0.05). However, when VAT was included as a covariate, it attenuated these trends (all P-trend < 0.05). In adolescents, higher fructose consumption is associated with multiple markers of cardiometabolic risk, but it appears that these relationships are mediated by visceral obesity.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalJournal of Nutrition
Volume142
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Adiposity
Fructose
Abdominal Fat
Intra-Abdominal Fat
Fats
Adiponectin
C-Reactive Protein
Fasting
Accelerometry
Exercise
Blood Pressure
Glucose
Abdominal Obesity
Energy Intake
Social Class
HDL Cholesterol
Sucrose
Linear Models
Age Groups
Insulin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Greater fructose consumption is associated with cardiometabolic riskmarkers and visceral adiposity in adolescents. / Pollock, Norman K.; Bundy, Vanessa; Kanto, William; Davis, Catherine Lucy; Bernard, Paul J.; Zhu, Haidong; Gutin, Bernard; Dong, Yanbin.

In: Journal of Nutrition, Vol. 142, No. 2, 01.02.2012, p. 251-257.

Research output: Contribution to journalArticle

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