Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The environmental determinants of diabetes in the young study

Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, William Hagopian, Jeffrey Krischer, Åke Lernmark, Jin Xiong She, Olli Simell, Jorma Toppari, Anette G. Ziegler, Marian Rewers

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.

Original languageEnglish (US)
Pages (from-to)1988-1995
Number of pages8
JournalDiabetes
Volume65
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Autoimmunity
Type 1 Diabetes Mellitus
Weights and Measures
Growth
Body Size
Finland
Proportional Hazards Models
Sweden
Autoantibodies
Germany

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study. / Larsson, Helena Elding; Vehik, Kendra; Haller, Michael J.; Liu, Xiang; Akolkar, Beena; Hagopian, William; Krischer, Jeffrey; Lernmark, Åke; She, Jin Xiong; Simell, Olli; Toppari, Jorma; Ziegler, Anette G.; Rewers, Marian.

In: Diabetes, Vol. 65, No. 7, 01.07.2016, p. 1988-1995.

Research output: Contribution to journalArticle

Larsson, HE, Vehik, K, Haller, MJ, Liu, X, Akolkar, B, Hagopian, W, Krischer, J, Lernmark, Å, She, JX, Simell, O, Toppari, J, Ziegler, AG & Rewers, M 2016, 'Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The environmental determinants of diabetes in the young study', Diabetes, vol. 65, no. 7, pp. 1988-1995. https://doi.org/10.2337/db15-1180
Larsson, Helena Elding ; Vehik, Kendra ; Haller, Michael J. ; Liu, Xiang ; Akolkar, Beena ; Hagopian, William ; Krischer, Jeffrey ; Lernmark, Åke ; She, Jin Xiong ; Simell, Olli ; Toppari, Jorma ; Ziegler, Anette G. ; Rewers, Marian. / Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study. In: Diabetes. 2016 ; Vol. 65, No. 7. pp. 1988-1995.
@article{bddec6fcf64744c495e53c8573176957,
title = "Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The environmental determinants of diabetes in the young study",
abstract = "Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95{\%} CI 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95{\%} CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95{\%} CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.",
author = "Larsson, {Helena Elding} and Kendra Vehik and Haller, {Michael J.} and Xiang Liu and Beena Akolkar and William Hagopian and Jeffrey Krischer and {\AA}ke Lernmark and She, {Jin Xiong} and Olli Simell and Jorma Toppari and Ziegler, {Anette G.} and Marian Rewers",
year = "2016",
month = "7",
day = "1",
doi = "10.2337/db15-1180",
language = "English (US)",
volume = "65",
pages = "1988--1995",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "7",

}

TY - JOUR

T1 - Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood

T2 - The environmental determinants of diabetes in the young study

AU - Larsson, Helena Elding

AU - Vehik, Kendra

AU - Haller, Michael J.

AU - Liu, Xiang

AU - Akolkar, Beena

AU - Hagopian, William

AU - Krischer, Jeffrey

AU - Lernmark, Åke

AU - She, Jin Xiong

AU - Simell, Olli

AU - Toppari, Jorma

AU - Ziegler, Anette G.

AU - Rewers, Marian

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.

AB - Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.

UR - http://www.scopus.com/inward/record.url?scp=84975797049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975797049&partnerID=8YFLogxK

U2 - 10.2337/db15-1180

DO - 10.2337/db15-1180

M3 - Article

C2 - 26993064

AN - SCOPUS:84975797049

VL - 65

SP - 1988

EP - 1995

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -