Abstract
Data presented provide evidence for the production of a GHRF by carcinoid and pancreatic islet tumors which stimulates GH overproduction by the pituitary leading to acromegaly and to pituitary tumor formation. These features, which constitute an 'ectopic GHRF syndrome', provide an explanation for the association of pituitary tumors with carcinoid and pancreatic islet tumors of the multiple endocrine neoplasia syndrome, Type I, and indicate that consideration of an extrapituitary tumor is warranted in every patient with acromegaly. These tumors produce both GHRF and somatostatin and the ultimate clinical expression undoubtedly reflects the ratio of release of these two factors into circulation. The identity of the GHRF in various tumors remains to be established as does the relationship by hypothalamic GHRF. However, the results indicate that excess secretion of GHRF can produce not only enhanced GH secretion but can also lead to pituitary tumor formation, and, therefore, provide evidence to support the hypothesis that at least some GH-secreting pituitary tumors are caused by hypersecretion of a hypothalamic GHRF.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions of the Association of American Physicians |
| Pages | 77-88 |
| Number of pages | 12 |
| Volume | Vol 92 |
| State | Published - Dec 1 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Growth hormone-releasing activity in extracts of bronchial carcinoid and pancreatic islet tumors associated with acromegaly. / Frohman, L. A.; Szabo, M.; Stachura, M. E.; Berelowitz, M.
Transactions of the Association of American Physicians. Vol. Vol 92 1979. p. 77-88.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Growth hormone-releasing activity in extracts of bronchial carcinoid and pancreatic islet tumors associated with acromegaly
AU - Frohman, L. A.
AU - Szabo, M.
AU - Stachura, M. E.
AU - Berelowitz, M.
PY - 1979/12/1
Y1 - 1979/12/1
N2 - Data presented provide evidence for the production of a GHRF by carcinoid and pancreatic islet tumors which stimulates GH overproduction by the pituitary leading to acromegaly and to pituitary tumor formation. These features, which constitute an 'ectopic GHRF syndrome', provide an explanation for the association of pituitary tumors with carcinoid and pancreatic islet tumors of the multiple endocrine neoplasia syndrome, Type I, and indicate that consideration of an extrapituitary tumor is warranted in every patient with acromegaly. These tumors produce both GHRF and somatostatin and the ultimate clinical expression undoubtedly reflects the ratio of release of these two factors into circulation. The identity of the GHRF in various tumors remains to be established as does the relationship by hypothalamic GHRF. However, the results indicate that excess secretion of GHRF can produce not only enhanced GH secretion but can also lead to pituitary tumor formation, and, therefore, provide evidence to support the hypothesis that at least some GH-secreting pituitary tumors are caused by hypersecretion of a hypothalamic GHRF.
AB - Data presented provide evidence for the production of a GHRF by carcinoid and pancreatic islet tumors which stimulates GH overproduction by the pituitary leading to acromegaly and to pituitary tumor formation. These features, which constitute an 'ectopic GHRF syndrome', provide an explanation for the association of pituitary tumors with carcinoid and pancreatic islet tumors of the multiple endocrine neoplasia syndrome, Type I, and indicate that consideration of an extrapituitary tumor is warranted in every patient with acromegaly. These tumors produce both GHRF and somatostatin and the ultimate clinical expression undoubtedly reflects the ratio of release of these two factors into circulation. The identity of the GHRF in various tumors remains to be established as does the relationship by hypothalamic GHRF. However, the results indicate that excess secretion of GHRF can produce not only enhanced GH secretion but can also lead to pituitary tumor formation, and, therefore, provide evidence to support the hypothesis that at least some GH-secreting pituitary tumors are caused by hypersecretion of a hypothalamic GHRF.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018653599&partnerID=8YFLogxK
M3 - Chapter
C2 - 232947
AN - SCOPUS:0018653599
VL - Vol 92
SP - 77
EP - 88
BT - Transactions of the Association of American Physicians
ER -