Growth of skeletal muscle from patients with amyotrophic lateral sclerosis transplanted into nude mice

A. K. Gulati, M. H. Rivner, M. Shamsnia, T. R. Swift, G. S. Sohal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We studied the fate of skeletal muscle obtained from patients with amyotrophic lateral sclerosis (ALS) after transplantation into immunodeficient nude mice. The transplanted muscle consistently survived in the nude mice without immunological rejection. The myofibers in these muscles underwent degeneration, followed by regeneration, maturation, and eventual functional innervation by the mouse motor neurons. The ability to grow diseased human muscle successfully over a prolonged period in nude mice offers an in vivo model to study the etiology of ALS and possibly of other neuromuscular disorders.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalMuscle & Nerve
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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