Growth/differentiation factor-5: Pre-clinical and clinical evaluations of periodontal regeneration and alveolar augmentation - Review

Jaebum Lee, Ulf M E Wikesjö

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: Growth/differentiation factor-5 (GDF-5) plays critical roles in mesenchymal cell differentiation and stimulates human periodontal ligament cell proliferation. Potentially, GDF-5 may also play roles in wound healing including periodontal regeneration and alveolar augmentation. The objective of this review was to provide up-to-date information from pre-clinical/clinical studies evaluating GDF-5 for these indications. Methods: A comprehensive search using PubMed and Google search engines was conducted to identify reports on GDF-5 applied to periodontal and alveolar indications. Two reviewers independently screened the titles and abstracts from a total of 479 reports. Full-length articles of 17 pre-clinical and four clinical studies were selected and reviewed. Results: Canine-, porcine- and non-human primate-based models as well as human clinical trials were used in the evaluation of GDF-5 in support of periodontal regeneration and alveolar augmentation. An absorbable collagen sponge (ACS), β-tricalcium phosphate (β-TCP) and a poly(lactic-co-glycolic) acid (PLGA) were evaluated as candidate carriers for GDF-5 using various dose and healing intervals demonstrating significantly enhanced periodontal regeneration/alveolar augmentation including cementum, periodontal ligament and alveolar bone with limited, if any, adverse effects. Conclusion: Growth/differentiation factor-5 supports periodontal regeneration/alveolar augmentation without aberrant healing events documented in qualified pre-clinical models and clinical pilot studies. In perspective, GDF-5 appears a promising technology for periodontal regeneration/alveolar augmentation.

Original languageEnglish (US)
Pages (from-to)797-805
Number of pages9
JournalJournal of Clinical Periodontology
Volume41
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Growth Differentiation Factor 5
Regeneration
Periodontal Ligament
Dental Cementum
Search Engine
Porifera
PubMed
Wound Healing
Primates
Canidae
Cell Differentiation
Swine
Collagen
Cell Proliferation
Clinical Trials
Technology

Keywords

  • alveolar bone
  • dental implants
  • GDF-5
  • periodontal regeneration
  • sinus augmentation

ASJC Scopus subject areas

  • Periodontics
  • Medicine(all)

Cite this

Growth/differentiation factor-5 : Pre-clinical and clinical evaluations of periodontal regeneration and alveolar augmentation - Review. / Lee, Jaebum; Wikesjö, Ulf M E.

In: Journal of Clinical Periodontology, Vol. 41, No. 8, 01.01.2014, p. 797-805.

Research output: Contribution to journalArticle

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