Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study

Xiaoyang Zhou, Jianfeng Huang, Jianhong Chen, Shaoyong Su, Runsheng Chen, Dongfeng Gu

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Matrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population.The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls.The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the - 1612 5A/6A polymorphism.We conclude that the MMP3 - 1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

Original languageEnglish (US)
Pages (from-to)867-873
Number of pages7
JournalThrombosis and Haemostasis
Volume92
Issue number4
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

Fingerprint

Matrix Metalloproteinase 3
Haplotypes
Atherosclerosis
Myocardial Infarction
Population
Genes
Alleles
Odds Ratio
Confidence Intervals
Beijing
Linkage Disequilibrium
Gene Frequency
Logistic Models
Regression Analysis

Keywords

  • Haplotype
  • Metalloproteinase
  • Myocardial infarction
  • Polymorphism

ASJC Scopus subject areas

  • Hematology

Cite this

Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study. / Zhou, Xiaoyang; Huang, Jianfeng; Chen, Jianhong; Su, Shaoyong; Chen, Runsheng; Gu, Dongfeng.

In: Thrombosis and Haemostasis, Vol. 92, No. 4, 01.10.2004, p. 867-873.

Research output: Contribution to journalArticle

Zhou, Xiaoyang ; Huang, Jianfeng ; Chen, Jianhong ; Su, Shaoyong ; Chen, Runsheng ; Gu, Dongfeng. / Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study. In: Thrombosis and Haemostasis. 2004 ; Vol. 92, No. 4. pp. 867-873.
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