Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study

Xiaoyang Zhou, Jianfeng Huang, Jianhong Chen, Shaoyong Su, Runsheng Chen, Dongfeng Gu

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Matrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population.The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls.The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the - 1612 5A/6A polymorphism.We conclude that the MMP3 - 1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

Original languageEnglish (US)
Pages (from-to)867-873
Number of pages7
JournalThrombosis and Haemostasis
Volume92
Issue number4
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

Keywords

  • Haplotype
  • Metalloproteinase
  • Myocardial infarction
  • Polymorphism

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study'. Together they form a unique fingerprint.

  • Cite this