HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson, M. Ramachandran, B. B. Webber, Ferdane Kutlar, L. F. Hazelnood, D. Barnett, N. V. Hirschler, T. H.J. Huisman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalHemoglobin
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1991

Fingerprint

Heme
Substitution reactions
Amino Acid Substitution
Oxygen
Amino Acids
hemoglobin Okazaki
hemoglobin Cleveland
hemoglobin D Punjab

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Wilson, J. B., Ramachandran, M., Webber, B. B., Kutlar, F., Hazelnood, L. F., Barnett, D., ... Huisman, T. H. J. (1991). HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN. Hemoglobin, 15(4), 269-278. https://doi.org/10.3109/03630269109027879

HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN. / Wilson, J. B.; Ramachandran, M.; Webber, B. B.; Kutlar, Ferdane; Hazelnood, L. F.; Barnett, D.; Hirschler, N. V.; Huisman, T. H.J.

In: Hemoglobin, Vol. 15, No. 4, 01.01.1991, p. 269-278.

Research output: Contribution to journalArticle

Wilson, JB, Ramachandran, M, Webber, BB, Kutlar, F, Hazelnood, LF, Barnett, D, Hirschler, NV & Huisman, THJ 1991, 'HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN', Hemoglobin, vol. 15, no. 4, pp. 269-278. https://doi.org/10.3109/03630269109027879
Wilson JB, Ramachandran M, Webber BB, Kutlar F, Hazelnood LF, Barnett D et al. HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN. Hemoglobin. 1991 Jan 1;15(4):269-278. https://doi.org/10.3109/03630269109027879
Wilson, J. B. ; Ramachandran, M. ; Webber, B. B. ; Kutlar, Ferdane ; Hazelnood, L. F. ; Barnett, D. ; Hirschler, N. V. ; Huisman, T. H.J. / HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN. In: Hemoglobin. 1991 ; Vol. 15, No. 4. pp. 269-278.
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