HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson; M. Ramachandran; B. B. Webber; F. Kutlar; L. F. Hazelnood; D. Barnett; N. V. Hirschler; T. H.J. Huisman

doi:10.3109/03630269109027879

HB Cleveland or α₂β₂93(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson, M. Ramachandran, B. B. Webber, F. Kutlar, L. F. Hazelnood, D. Barnett, N. V. Hirschler, T. H.J. Huisman

Hematology and Oncology

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Hemoglobin
Volume	15
Issue number	4
DOIs	https://doi.org/10.3109/03630269109027879
Publication status	Published - Jan 1 1991

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ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

Cite this

Wilson, J. B., Ramachandran, M., Webber, B. B., Kutlar, F., Hazelnood, L. F., Barnett, D., ... Huisman, T. H. J. (1991). HB Cleveland or α₂β₂93(f9)CYS→ARG;121(GH4)GLU→GLN. Hemoglobin, 15(4), 269-278. https://doi.org/10.3109/03630269109027879

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AU - Kutlar, F.

AU - Hazelnood, L. F.

AU - Barnett, D.

AU - Hirschler, N. V.

AU - Huisman, T. H.J.

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10.3109/03630269109027879