HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson, M. Ramachandran, B. B. Webber, F. Kutlar, L. F. Hazelnood, D. Barnett, N. V. Hirschler, T. H.J. Huisman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalHemoglobin
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

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