Abstract
Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.
Original language | English (US) |
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Pages (from-to) | 269-278 |
Number of pages | 10 |
Journal | Hemoglobin |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1991 |
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ASJC Scopus subject areas
- Hematology
- Genetics(clinical)
- Clinical Biochemistry
- Biochemistry, medical
Cite this
HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN. / Wilson, J. B.; Ramachandran, M.; Webber, B. B.; Kutlar, Ferdane; Hazelnood, L. F.; Barnett, D.; Hirschler, N. V.; Huisman, T. H.J.
In: Hemoglobin, Vol. 15, No. 4, 01.01.1991, p. 269-278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN
AU - Wilson, J. B.
AU - Ramachandran, M.
AU - Webber, B. B.
AU - Kutlar, Ferdane
AU - Hazelnood, L. F.
AU - Barnett, D.
AU - Hirschler, N. V.
AU - Huisman, T. H.J.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.
AB - Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.
UR - http://www.scopus.com/inward/record.url?scp=0025830709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025830709&partnerID=8YFLogxK
U2 - 10.3109/03630269109027879
DO - 10.3109/03630269109027879
M3 - Article
C2 - 1787096
AN - SCOPUS:0025830709
VL - 15
SP - 269
EP - 278
JO - Hemoglobin
JF - Hemoglobin
SN - 0363-0269
IS - 4
ER -