HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson; M. Ramachandran; B. B. Webber; F. Kutlar; L. F. Hazelnood; D. Barnett; N. V. Hirschler; T. H.J. Huisman

doi:10.3109/03630269109027879

HB Cleveland or α₂β₂93(f9)CYS→ARG;121(GH4)GLU→GLN

J. B. Wilson, M. Ramachandran, B. B. Webber, F. Kutlar, L. F. Hazelnood, D. Barnett, N. V. Hirschler, T. H.J. Huisman

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Hemoglobin
Volume	15
Issue number	4
DOIs	https://doi.org/10.3109/03630269109027879
State	Published - Jan 1 1991

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

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title = "HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN",

abstract = "Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.",

author = "Wilson, {J. B.} and M. Ramachandran and Webber, {B. B.} and F. Kutlar and Hazelnood, {L. F.} and D. Barnett and Hirschler, {N. V.} and Huisman, {T. H.J.}",

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T1 - HB Cleveland or α2β293(f9)CYS→ARG;121(GH4)GLU→GLN

AU - Wilson, J. B.

AU - Ramachandran, M.

AU - Webber, B. B.

AU - Kutlar, F.

AU - Hazelnood, L. F.

AU - Barnett, D.

AU - Hirschler, N. V.

AU - Huisman, T. H.J.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

AB - Hb Cleveland is characterized by two amino acid Substitutions, namely β121(GH4)Glu→Gln as in Hb D-Los Angeles and β93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13th β chain variant with two substitutions that has been described thus far.

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JO - Hemoglobin

JF - Hemoglobin

SN - 0363-0269

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